Evidence map›Paper›PMID 40009443›Full record

ArticleeLife2025

Control of ciliary transcriptional programs during spermatogenesis by antagonistic transcription factors.

Weihua Wang, Junqiao Xing, Xiqi Zhang, Hongni Liu, Xingyu Liu, Haochen Jiang, Cheng Xu, Xue Zhao, Zhangfeng Hu

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Cilia and transcription: a mini review.Frontiers in cell and developmental biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Weihua Wang *Institute of Microalgae Synthetic Biology and Green Manufacturing, School of Life Sciences, Jianghan University, Wuhan, China.ORCID https://orcid.org/0009-0007-3965-7375
Junqiao Xing *Institute of Microalgae Synthetic Biology and Green Manufacturing, School of Life Sciences, Jianghan University, Wuhan, China.
Xiqi Zhang *Institute of Microalgae Synthetic Biology and Green Manufacturing, School of Life Sciences, Jianghan University, Wuhan, China.
Hongni LiuInstitute of Microalgae Synthetic Biology and Green Manufacturing, School of Life Sciences, Jianghan University, Wuhan, China.
Xingyu LiuInstitute of Microalgae Synthetic Biology and Green Manufacturing, School of Life Sciences, Jianghan University, Wuhan, China.
Haochen JiangInstitute of Microalgae Synthetic Biology and Green Manufacturing, School of Life Sciences, Jianghan University, Wuhan, China.ORCID https://orcid.org/0009-0003-4254-6765
Cheng XuInstitute of Microalgae Synthetic Biology and Green Manufacturing, School of Life Sciences, Jianghan University, Wuhan, China.
Xue ZhaoInstitute of Microalgae Synthetic Biology and Green Manufacturing, School of Life Sciences, Jianghan University, Wuhan, China.
Zhangfeng HuInstitute of Microalgae Synthetic Biology and Green Manufacturing, School of Life Sciences, Jianghan University, Wuhan, China.ORCID https://orcid.org/0000-0002-4841-8073

Funding

Major Special Funding Program for First-class Discipline Construction of Jianghan University 2023XKZ021National Key Research and Development Program of China 2020YFA0907400National Natural Science Foundation of China 32170702National Natural Science Foundation of China 82000828
6 · The paper itself

Abstract

Existence of cilia in the last eukaryotic common ancestor raises a fundamental question in biology: how the transcriptional regulation of ciliogenesis has evolved? One conceptual answer to this question is by an ancient transcription factor regulating ciliary gene expression in both uni- and multicellular organisms, but examples of such transcription factors in eukaryotes are lacking. Previously, we showed that an ancient transcription factor X chromosome-associated protein 5 (Xap5) is required for flagellar assembly in

Indexed as

CiliaGene Expression RegulationSpermatogenesisTranscription FactorsTranscription, GeneticAnimalsMaleMiceMice, KnockoutTranscription Factorsantagonistic transcription factorscell biologyciliamousespermatogenesistranscriptional regulationXap5Xap5l

Identifiers

PMID40009443
PMCPMC11864758

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.