Evidence map›Paper›PMID 40009330›Full record

ArticleProbiotics and antimicrobial proteins2025

Modulation of the Sporulation Dynamics in the Plant-Probiotic Bacillus velezensis 83 via Carbon and Quorum-Sensing Metabolites.

Esmeralda Yazmín Soriano-Peña, Agustín Luna-Bulbarela, Sergio Andrés Cristiano-Fajardo, Enrique Galindo, Leobardo Serrano-Carreón

Abstract read
In one paragraph

Article in Probiotics and antimicrobial proteins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Esmeralda Yazmín Soriano-Peña *Departamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, C.P.62210, Cuernavaca, Morelos, México.
Agustín Luna-Bulbarela *Departamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, C.P.62210, Cuernavaca, Morelos, México.
Sergio Andrés Cristiano-FajardoDepartamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, C.P.62210, Cuernavaca, Morelos, México.
Enrique GalindoDepartamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, C.P.62210, Cuernavaca, Morelos, México. enrique.galindo@ibt.unam.mx.
Leobardo Serrano-CarreónDepartamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, C.P.62210, Cuernavaca, Morelos, México. leobardo.serrano@ibt.unam.mx.

Funding

Consejo Nacional de Humanidades, Ciencias y Tecnologías 404462Consejo Nacional de Humanidades, Ciencias y Tecnologías 463764Universidad Nacional Autónoma de México IG200724
6 · The paper itself

Abstract

Spore-forming Bacilli, such as the plant-associated Bacillus velezensis strains, are widely used as probiotics, known for their safety and substantial health benefits for both animal and plant species. Through differentiation pathways mediated by quorum-sensing metabolites (QSMs), these bacteria develop multiple isogenic subpopulations with distinct phenotypes and ecological functions, including motile cells, matrix-producing/cannibalistic cells, competent cells, spores, and others. However, the heterogeneity in Bacillus populations is a significant limitation for the development of spore-based probiotics, as nutrients supplied during fermentation are consumed through non-target pathways. One of these pathways is the generation of overflow metabolites (OMs), including acetoin and 2,3-butanediol. This study elucidates, using a 2

Indexed as

BacillusCarbonProbioticsQuorum SensingSpores, BacterialAcetoinButylene GlycolsPlants2,3-butylene glycolAcetoinButylene GlycolsCarbonBacillus velezensisCSF peptideOverflow metabolitesQuorum-sensing metabolitesSpore production

Identifiers

PMID40009330
PMCPMC12532671

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.