Evidence map›Paper›PMID 40009327›Full record

ArticleMolecular imaging and biology2025

Evaluation of [

Mani Salarian, Shuanglong Liu, Hsiu-Ming Tsai, Shannon N Leslie, Thomas Hayes, Su-Tang Lo, Anna K Szardenings, Wei Zhang, Gang Chen, Christine Sandiego and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mani SalarianJohnson & Johnson, 3210 Merryfield Row, San Diego, CA, 92121, USA.
Shuanglong LiuJohnson & Johnson, 3210 Merryfield Row, San Diego, CA, 92121, USA.
Hsiu-Ming TsaiJohnson & Johnson, 3210 Merryfield Row, San Diego, CA, 92121, USA.
Shannon N LeslieJohnson & Johnson, 3210 Merryfield Row, San Diego, CA, 92121, USA.
Thomas HayesJohnson & Johnson, 3210 Merryfield Row, San Diego, CA, 92121, USA.
Su-Tang LoJohnson & Johnson, 3210 Merryfield Row, San Diego, CA, 92121, USA.
Anna K SzardeningsJohnson & Johnson, 3210 Merryfield Row, San Diego, CA, 92121, USA.
Wei ZhangJohnson & Johnson, 3210 Merryfield Row, San Diego, CA, 92121, USA.
Gang ChenJohnson & Johnson, 3210 Merryfield Row, San Diego, CA, 92121, USA.
Christine SandiegoInvicro, New Haven, CT, USA.
Lisa WellsInvicro, London, UK.
Dileep G NairJohnson & Johnson, 3210 Merryfield Row, San Diego, CA, 92121, USA.
Hartmuth C KolbJohnson & Johnson, 3210 Merryfield Row, San Diego, CA, 92121, USA.
Chunfang A XiaJohnson & Johnson, 3210 Merryfield Row, San Diego, CA, 92121, USA. cxia1@its.jnj.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeColony-stimulating factor 1 receptor (CSF1R) signaling plays a pivotal role in neuroinflammation, driving microglia proliferation and activation. CSF1R is considered a hallmark of inflammation in many neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD). Our study aims to evaluate the potential value of 5-cyano-N-(4-(4-(2-([ PROCEDURES: A cell-based MSD assay was used to measure the IC

resultsJNJ-CSF1R-1 is a 12 nM (IC

conclusion​[

Indexed as

Fluorine RadioisotopesFuransPiperazinesPositron-Emission TomographyReceptors, Granulocyte-Macrophage Colony-Stimulating FactorAnimalsBrainHumansLigandsMaleMiceRadiopharmaceuticalsReceptor, Macrophage Colony-Stimulating FactorCSF1R protein, humanFluorine-18Fluorine RadioisotopesFuransLigandsPiperazinesRadiopharmaceuticalsReceptor, Macrophage Colony-Stimulating FactorReceptors, Granulocyte-Macrophage Colony-Stimulating FactorAlzheimer’s diseaseColony-stimulating factor 1 receptorNeuroinflammationPET/CT

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.