Evidence map›Paper›PMID 40009283›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2025

Evaluation of potential antiparasitic effect of ZnO nanoparticles on experimental cryptosporidiosis in immunosuppressed mice.

Salhah Hamed Alrefaee, Faizah S Aljohani, M El-Khatib, Yahya H Shahin, Bassma H Elwakil, Sendianah H Shahin, Sara H Akl, Esraa Abdelhamid Moneer, Amira Abd-Elfattah Darwish

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Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Salhah Hamed AlrefaeeDepartment of Chemistry, College of Science, Taibah University, 30799, Yanbu, Saudi Arabia.
Faizah S AljohaniDepartment of Chemistry, College of Science, Taibah University, 30002, Al-Madinah Al-Munawarah, Saudi Arabia.
M El-KhatibDepartment of Basic Sciences, Faculty of Computer Science and Artificial Intelligence, Pharos University, Alexandria, Egypt.
Yahya H ShahinDepartment of Medical Laboratory Technology, Faculty of Health and Medical Techniques, Almaaqal University, Basrah, Iraq.
Bassma H ElwakilDepartment of Medical Laboratory Technology, Faculty of Applied Health Sciences Technology, Pharos University in Alexandria, Alexandria, 21526, Egypt. bassma.hassan@pua.edu.eg.
Sendianah H ShahinDepartment of Economics and Agribusiness, Faculty of Agriculture, Alexandria University, Alexandria, Egypt.
Sara H AklDepartment of Medical Laboratory Technology, Faculty of Applied Health Sciences Technology, Pharos University in Alexandria, Alexandria, 21526, Egypt.
Esraa Abdelhamid MoneerDepartment of Medical Laboratory Technology, Faculty of Applied Health Sciences Technology, Pharos University in Alexandria, Alexandria, 21526, Egypt.
Amira Abd-Elfattah DarwishDepartment of Medical Laboratory Technology, Faculty of Applied Health Sciences Technology, Pharos University in Alexandria, Alexandria, 21526, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cryptosporidium is a food and water-borne enteric protozoan that infects a wide range of vertebrates, causing life-threatening complications, particularly in immunocompromised hosts. The absence of effective anti-cryptosporidial medications could be attributed to the parasite's specific intestinal location, as well as the lack of research into the mechanism by which the protozoan impairs intestine cellular function. The present work aimed to evaluate the in vivo efficacy of zinc nanoparticles in the treatment of experimental cryptosporidiosis infection in immunosuppressed mice. Small-sized ZnO-NPs revealed better treatment efficacy than Large-sized ZnO-NPs in all studies. Nitazoxanide-treated group revealed the highest percentage reduction of the oocyst's counts followed by the small-sized ZnO-NPs treated group. The small-sized ZnO-NPs treated mice group showed a minimal inflammatory effect in all examined treated tissues when compared to the infected non-treated group. The morphological structure of the oocysts was examined using SEM indicating variable degrees of morphological changes in the treated mice. Moreover, the levels of biochemical analyses were significantly lower in the treated group. The histopathological study revealed the significant effect of small-sized ZnO-NPs in treating cryptosporidiosis.

Indexed as

Antiparasitic AgentsCryptosporidiosisMetal NanoparticlesNanoparticlesZinc OxideAnimalsCryptosporidium parvumImmunocompromised HostMiceNitro CompoundsOocystsThiazolesAntiparasitic AgentsnitazoxanideNitro CompoundsThiazolesZinc OxideImmunocompromisedMetalsNitazoxanideZinc

Identifiers

PMID40009283

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.