Intestinal fatty-acid binding protein as a diagnosis marker in younger with celiac diseases.

Ali A Taha, Shaimaa Ibrahim Khalil, Ammar M K Al-Azzawi, Ekhlas Abdallah Hassan

Abstract read

In one paragraph

Article in Irish journal of medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ali A TahaDepartment of Forensic Science, College of Science, University of Diyala, Baquba, Diyala, Iraq.

Shaimaa Ibrahim KhalilDepartment of Chemistry, College of Science, University of Diyala, Baquba, Diyala, Iraq.

Ammar M K Al-AzzawiDepartment of Chemistry, College of Education for Pure Science, University of Diyala, Baquba, Iraq.

Ekhlas Abdallah HassanDepartment of Chemistry, College of Science, University of Diyala, Baquba, Diyala, Iraq. ekhlasbiochemistry@gmail.com.ORCID http://orcid.org/0000-0001-7655-6230

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCeliac disease (CD) is an autoimmune disorder known to be highly associated with autoimmune manifestations and genetic factors. The aim of this paper was to assess the diagnostic accuracy of serum I-FABP in CD patients.

methodsFifty patients with CD were classified into two groups: (30) exhibiting positive titers of tTG-IgA test and tTG-IgG test value more than 18 AU/mL and (20) patients with a potential diagnosis of CD (equivocal titers of IgG and IgA tTG 12-18 AU/mL) for comparison, as well as 50 healthy individuals were included as a control. The ELISA Kit was used to measure serum I-FABP where serum iron and serum ferritin were measured through the standard methods on the Smart-150 autoanalyzer biochemistry, instead of IgG and IgA tTG that was determined using an immunoenzymatically technique.

resultsThe concentration of serum I-FABP in the CD group was significantly higher than that of the healthy subjects (p < 0.05). There was a significant difference in the serum I-FABP concentrations between two patients. There were substantial positive connections between serum 1-FAPB concentration and IgG, as well as strong positivity correlations between serum 1-FAPB and serum IgA Ttg in CD patients. The concentration of serum 1-FAPB, on the other hand, had no significant association with the anti Ttg IgG and serum IgA Ttg. The area under the curve was excellent (AUC = 1, p = 0.0001), with high diagnostic accuracy (96.2) in differentiating CD from the healthy subject group.

conclusionI-FABP levels in the sera of were shown to be higher and I-FABP levels were shown to be significantly linked between activated immune response (IgA-tTG) and enterocyte damage (I-FABP) in CD patients.

Indexed as

Celiac DiseaseFatty Acid-Binding ProteinsAdolescentAdultBiomarkersCase-Control StudiesFemaleHumansImmunoglobulin AImmunoglobulin GMaleMiddle AgedYoung AdultBiomarkersFatty Acid-Binding ProteinsImmunoglobulin AImmunoglobulin GCeliac diseasesIgG and IgA tissue transglutaminaseIntestinal fatty-acid binding protein

Identifiers

PMID40009278

DOI10.3390/nu12082176

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.