Evidence map›Paper›PMID 40009219›Full record

ArticleEuropean journal of applied physiology2025

Effect of burn injury size on cardiovascular responses to exercise in the heat.

Zachary J McKenna, Whitley C Atkins, Elizabeth A Gideon, Josh Foster, Isa A Farooqi, Craig G Crandall

Abstract read
In one paragraph

Article in European journal of applied physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zachary J McKennaInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Whitley C AtkinsDepartment of Health, Exercise and Sports Sciences, University of New Mexico, Albuquerque, NM, USA.
Elizabeth A GideonInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Josh FosterCentre for Human and Applied Physiological Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Isa A FarooqiInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Craig G CrandallInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA. CraigCrandall@texashealth.org.ORCID http://orcid.org/0000-0001-7792-9713

Funding

Exercise in Burn Survivors - Administrative Supplement for EquipmentR01GM068865 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI CRANDALL, CRAIG G · 2003 to 2023
$7.0M
Cardiovascular and thermoregulatory consequences of severe burn injuries - RevisionR35GM152112 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI CRAIG G CRANDALL · 2024 to 2026
$1.4M
Low-energy cooling strategies to reduce the thermal, cardiovascular, and renal consequences of heat waves in the elderly.F32HL168826 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI MCKENNA, ZACHARY JOHN · 2024 to 2025
$149k
NHLBI NIH HHS F32 HL168826NHLBI NIH HHS F32HL168826NIGMS NIH HHS R01 GM068865NIGMS NIH HHS R01GM068865NIGMS NIH HHS R35 GM152112
6 · The paper itself

Abstract

We tested the hypothesis that due to well recognized thermoregulatory impairments, resulting in greater thermal strain, adults with well healed burn injuries will have heightened cardiovascular responses to exercise in the heat. Adults with burn injuries covering 20-40% body surface area (n = 10), > 40% body surface area (n = 11), and non-burned controls (n = 10) performed 1 h of treadmill walking at a fixed rate of metabolic heat production (~ 4.5 w/kg) in the heat (39 °C, 40% relative humidity). Core temperature, heart rate, stroke volume, and blood pressure were obtained at rest and during exercise. The increase in core temperature was 0.89 ± 0.40 °C for control, 0.92 ± 0.43 °C for 20-40%, and 1.30 ± 0.58 °C for > 40% (interaction: p = .08). Ending heart rate was greater in > 40% compared to control (142 ± 27 vs 118 ± 9 bpm; p = .03), however there was no difference between 20-40% and control (128 ± 24 vs 118 ± 9 bpm; p = .44). Ending rate pressure product was higher in the > 40% compared to control (21,326 ± 4327 vs 15,971 ± 2156 mmHg*bpm; p = .007), however there was no difference between 20-40% and control (18,698 ± 3741 vs 15,971 ± 2156 mmHg*bpm; p = .16). At 45-min into exercise, cardiac minute work was higher in the > 40% compared to control (577 ± 102 vs 467 ± 63 L/min*mmHg/m

Indexed as

BurnsExerciseHot TemperatureAdultBlood PressureBody Temperature RegulationFemaleHeart RateHumansMaleMiddle AgedStroke VolumeCardiacHeat stressStrainThermal

Identifiers

PMID40009219
PMCPMC12227285

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.