Evidence map›Paper›PMID 40009126›Full record

ArticleClinical journal of gastroenterology2025

A case of chronic hepatitis B complicated by systemic sarcoidosis that regressed following nucleos(t)ide analog therapy.

Shigeaki Semba, Yuji Teraoka, Hiroki Kamada, Naohiro Kato, Takeshi Mizumoto, Yuzuru Tamaru, Tsuyoshi Hatakeyama, Atsushi Yamaguchi, Hirotaka Kouno, Shigeto Yoshida

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Clinical journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shigeaki SembaDepartment of Endoscopy, NHO Kure Medical Center, Chugoku Cancer Center, Hiroshima, Japan.
Yuji TeraokaDepartment of Gastroenterology, NHO Kure Medical Center, Chugoku Cancer Center, 3-1, Aoyama-cho, Kure, Hiroshima, 737-0023, Japan. teraoka.yuji.ed@mail.hosp.go.jp.ORCID http://orcid.org/0009-0008-8589-6155
Hiroki KamadaDepartment of Endoscopy, NHO Kure Medical Center, Chugoku Cancer Center, Hiroshima, Japan.
Naohiro KatoDepartment of Endoscopy, NHO Kure Medical Center, Chugoku Cancer Center, Hiroshima, Japan.
Takeshi MizumotoDepartment of Endoscopy, NHO Kure Medical Center, Chugoku Cancer Center, Hiroshima, Japan.
Yuzuru TamaruDepartment of Endoscopy, NHO Kure Medical Center, Chugoku Cancer Center, Hiroshima, Japan.
Tsuyoshi HatakeyamaDepartment of Endoscopy, NHO Kure Medical Center, Chugoku Cancer Center, Hiroshima, Japan.
Atsushi YamaguchiDepartment of Gastroenterology, NHO Kure Medical Center, Chugoku Cancer Center, 3-1, Aoyama-cho, Kure, Hiroshima, 737-0023, Japan.
Hirotaka KounoDepartment of Gastroenterology, NHO Kure Medical Center, Chugoku Cancer Center, 3-1, Aoyama-cho, Kure, Hiroshima, 737-0023, Japan.
Shigeto YoshidaDepartment of Endoscopy, NHO Kure Medical Center, Chugoku Cancer Center, Hiroshima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, we report the case of a 75-year-old woman with systemic sarcoidosis complicated by chronic hepatitis B. She presented with high fever and fatigue, with imaging studies revealing multiple tumor nodules in the liver and spleen, along with generalized lymphadenopathy, leading to her admission to our hospital for further evaluation and treatment. Blood tests revealed chronic hepatitis B, and nucleoside analog therapy with entecavir was initiated before the sarcoidosis diagnosis. A liver biopsy confirmed sarcoidosis, and treatment continued without steroid use. Significant improvement in symptoms and tumor size reduction were observed within weeks. After 6 months of treatment, positron emission tomography/computed tomography showed further regression of the liver and spleen tumors, with no symptom recurrence. Given the rarity of sarcoidosis complicated by chronic hepatitis B, this case suggests that controlling hepatitis B virus infection with nucleos(t)ide analogs might improve sarcoidosis symptoms without steroid use. The immunologic mechanisms underlying this cooccurrence remain unclear, and such cases are extremely rare. Therefore, this case may contribute to the understanding and management of sarcoidosis in patients with concurrent chronic hepatitis B.

Indexed as

Antiviral AgentsGuanineHepatitis B, ChronicSarcoidosisAgedFemaleHumansPositron Emission Tomography Computed TomographyAntiviral AgentsentecavirGuanineEntecavirHepatitis B virusNucleos(t)ide analogSarcoidosis

Identifiers

PMID40009126

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.