Evidence map›Paper›PMID 40009053›Full record

ArticleJournal of applied gerontology : the official journal of the Southern Gerontological Society2025

Slowed Driving Reaction Time in Preclinical Alzheimer's Disease.

Pedram Ahmadnezhad, Jeffrey M Burns, Abiodun E Akinwuntan, Maud Ranchet, Alexandra Kondyli, Ganesh M Babulal, Jonathan D Mahnken, Hannes Devos

Abstract read
In one paragraph

Article in Journal of applied gerontology : the official journal of the Southern Gerontological Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pedram AhmadnezhadUniversity of Kansas Medical Center, Kansas City, KS, USA.
Jeffrey M BurnsUniversity of Kansas Alzheimer's Disease Research Center, University of Kansas Medical Center, Kansas City, KS, USA.
Abiodun E AkinwuntanUniversity of Kansas Medical Center, Kansas City, KS, USA.
Maud RanchetLESCOT, University Gustave Eiffel, Champs-sur-Marne, France.
Alexandra KondyliUniversity of Kansas, Lawrence, KS.
Ganesh M BabulalWashington University School of Medicine St Louis, St. Louis, MO USA.ORCID 0000-0001-7966-3509
Jonathan D MahnkenUniversity of Kansas Medical Center, Kansas City, KS, USA.
Hannes DevosUniversity of Kansas Medical Center, Kansas City, KS, USA.ORCID 0000-0002-8853-6840

Funding

University of Kansas Alzheimer's Disease Research Center (KU ADRC)P30AG072973 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Mohammad Haeri · 2021 to 2026
$25.3M
University of Kansas Alzheimer's Disease Core CentersP30AG035982 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SWERDLOW, RUSSELL H. · 2011 to 2020
$16.6M
Siemens Magnetom Verio MRI ScannerS10RR029577 · NCRR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BROOKS, WILLIAM M. · 2010 to 2010
$2.9M
Neurophysiological Changes in Pre-clinical Alzheimer's DiseaseK01AG058785 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI DEVOS, HANNES · 2019 to 2023
$638k
NCRR NIH HHS S10 RR029577NIA NIH HHS K01 AG058785NIA NIH HHS P30 AG035982NIA NIH HHS P30 AG072973
6 · The paper itself

Abstract

Driving reaction time (DRT) is one of the most important predictors of motor vehicle crashes in older adults. Although individuals with preclinical Alzheimer's disease (AD) show subtle cognitive changes that may affect driving, their DRT to emergency events has not been investigated. We compared DRT to an emergency event between 19 drivers with preclinical AD and 21 controls in a driving simulator. All drivers engaged in a car-following task with and without distracters. After the car-following event, a crash prompted participants to brake and maneuver around the accident scene. Drivers with preclinical AD took longer to respond to the emergency event compared to controls when they were not distracted by an additional task (7.56 ± 1.46 s v 6.42 ± 1.17 s;

Indexed as

Alzheimer DiseaseAutomobile DrivingReaction TimeAccidents, TrafficAgedAged, 80 and overCase-Control StudiesComputer SimulationFemaleHumansMalePilot ProjectsAlzheimercognitiondrivingolder adultspreclinicalreaction time

Identifiers

PMID40009053
PMCPMC12353288

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.