ArticleJournal of veterinary internal medicine
Longitudinal Evaluation of Vitamin D, Parathyroid Hormone, Antimicrobial Peptides, and Immunomodulatory Genes in Hospitalized Foals.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
backgroundInformation about the association of antimicrobial peptides with hypovitaminosis D in hospitalized foals is lacking. HYPOTHESIS/
objectivesWe aimed to longitudinally determine the association of serum concentrations of vitamin D metabolites, vitamin D binding protein (DBP), and parathyroid hormone (PTH) with antimicrobial peptides (β-defensin-1 and cathelicidin-1) and the mRNA expression of the vitamin D receptor (VDR), 1α-hydroxylase (CYP27B1), 24-hydroxylase (CYP24A1), toll-like receptor-4 (TLR-4), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), disease severity, and mortality in hospitalized foals. We hypothesized that hypovitaminosis D would be associated with decreased serum concentrations of antimicrobial peptides, disease severity, and mortality in hospitalized foals. ANIMALS: One hundred nine foals ≤ 72 h of age divided into hospitalized (n = 83; 60 septic, 23 sick nonseptic [SNS]) and healthy (n = 26) foals.
methodsBlood samples were collected on admission (0), and 24, 48, and 72 h after admission from healthy and hospitalized foals. Data were analyzed by repeated measure methods.
resultsSerum 25(OH)D, 1,25(OH) CONCLUSIONS AND CLINICAL IMPORTANCE: Decreased vitamin D metabolite concentrations and decreased antimicrobial peptide concentrations suggest that vitamin D has important immunomodulatory functions in newborn foals.
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