Trial reportEuropean journal of physical and rehabilitation medicine2025
Analgesic efficacy of transcranial combined peripheral magnetic stimulation in chronic nonspecific low back pain: a fNIRS study.
Trial report in European journal of physical and rehabilitation medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of non-invasive brain stimulation for chronic low back pain: a systematic review and meta-analysis of randomised controlled trials.Journal of neuroengineering and rehabilitation · 2026Pooled it
- Efficacy and cortical mechanisms of repetitive peripheral magnetic stimulation in non-specific neck and low back pain: a prospective, two-center, randomized, sham-controlled fNIRS study.Journal of translational medicine · 2026Trial
- Comparative Efficacy of Non-invasive Brain Stimulation for Pain, Anxiety, and Depression: A Systematic Review and Network Meta-analysis.Pain and therapy · 2026Review
- Review
- Biomechanical optimization of rolling manipulation for lumbar muscle strain: a study protocol of cerebral hemodynamic responses and clinical efficacy using fNIRS.Frontiers in neurology · 2026Article
- Research Trends and Insights in Chronic Nonspecific Low Back Pain: Bibliometric Analysis (1996-2025).Pain research & management · 2026Review
- Non-invasive brain stimulation for chronic low back pain: current techniques and future perspectives.Frontiers in human neuroscience · 2026Article
- Comparative Efficacy of Physical Agent Therapies for Chronic Low Back Pain-A Systematic Review and Network Meta-Analysis.Journal of pain research · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMagnetic stimulation has a potential therapeutic effect on patients with chronic nonspecific low back pain (CNLBP). However, the efficacy and underlying brain mechanisms of closed-loop magnetic stimulation for CNLBP remain unclear.
aimThis study aims to investigate the analgesic efficacy and brain activation of repetitive transcranial magnetic stimulation (rTMS) combined with repetitive peripheral magnetic stimulation (rPMS) in patients with CNLBP.
designThis was a single-center, double-blind, randomized controlled trial.
settingHuashan Hospital. POPULATION: CNLBP.
methodsThirty patients with CNLBP were randomly allocated into the experimental group and control group, with fifteen patients in each group. Patients in both groups received CNLBP-related health education. On this basis, patients in the experimental group received a two-week rTMS combined with rPMS treatment, while the control group received rPMS treatment combined with sham-rTMS stimulation. Visual analogue scale (VAS), Oswestry Disability Index (ODI), and Neurometer CPT sensory nerve quantitative detector were used to evaluate the participants before and after treatment. In addition, functional near-infrared imaging (fNIRS) was employed to ascertain participants' brain function.
resultsAfter treatment, both groups exhibited a significant decrease in VAS and ODI scores compared to their pre-treatment levels (all P<0.05). While there was no statistical significance between the two groups. Neurometer CPT revealed that the experimental group improved the pain threshold of C-fiber on the unaffected side (P=0.036). In addition, compared with the control group, the experimental group exhibited a notable increase in the activation of the somatosensory association cortex (SAC) region and an improvement in the functional connectivity of brain regions, including SAC and the primary motor cortex (PMC), after treatment.
conclusionsCombining rTMS with rPMS can significantly relieve pain and remodel brain regions in individuals with CNLBP. This closed-loop rehabilitation model paradigm merits additional clinical investigation and implementation. CLINICAL REHABILITATION IMPACT: Magnetic stimulation therapy based on closed-loop rehabilitation mode has a good prospect for clinical rehabilitation for patients with CNLBP.
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