Evidence map›Paper›PMID 40008892›Full record

ArticlemSphere2025

Cell differentiation controls iron assimilation in the choanoflagellate

Fredrick Leon, Jesus M Espinoza-Esparza, Vicki Deng, Maxwell C Coyle, Sarah Espinoza, David S Booth

Abstract read
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Fredrick LeonDepartment of Biochemistry and Biophysics, University of California, San Francisco School of Medicine, San Francisco, California, USA.ORCID 0009-0001-0525-091X
Jesus M Espinoza-EsparzaDepartment of Biochemistry and Biophysics, University of California, San Francisco School of Medicine, San Francisco, California, USA.
Vicki DengDepartment of Biochemistry and Biophysics, University of California, San Francisco School of Medicine, San Francisco, California, USA.
Maxwell C CoyleDepartment of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, California, USA.
Sarah EspinozaDepartment of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, California, USA.
David S BoothDepartment of Biochemistry and Biophysics, University of California, San Francisco School of Medicine, San Francisco, California, USA.ORCID 0000-0002-4724-4702

Funding

Tetrad: Genetics, Cell Biology, Biochemistry and Molecular Biology Training GrantT32GM139786 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Natalia Jura, David Paul Toczyski · 2021 to 2026
$6.5M
The ancestry of animal cell differentiation and pluripotencyR35GM147404 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI David Scott Booth · 2022 to 2026
$2.0M
Pacific Biosciences PacBio RS Single Molecule Real Time SequencerS10OD018174 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI ROKHSAR, DANIEL SOLEYMAN · 2014 to 2014
$600k
David and Lucile Packard Foundation (PF)HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM147404HHS | NIH | National Institute of General Medical Sciences (NIGMS) T32GM139786NIGMS NIH HHS R35 GM147404NIGMS NIH HHS T32 GM139786NIH HHS S10 OD018174NSF | National Science Foundation Graduate Research Fellowship Program (GRFP)
6 · The paper itself

Abstract

Marine microeukaryotes have evolved diverse cellular features that link their life histories to surrounding environments. How those dynamic life histories intersect with the ecological functions of microeukaryotes remains a frontier to understanding their roles in critical biogeochemical cycles. Choanoflagellates, phagotrophs that cycle nutrients through filter feeding, provide models to explore this intersection, for many choanoflagellate species transition between life history stages by differentiating into distinct cell types. Here, we report that cell differentiation in the marine choanoflagellate IMPORTANCE: This study examines how cell differentiation in a choanoflagellate enables the uptake of iron, an essential nutrient. Choanoflagellates are widespread, aquatic microeukaryotes that are the closest living relatives of animals. Similar to their animal relatives, we found that the model choanoflagellate,

Indexed as

Cell DifferentiationChoanoflagellataIronFMN ReductaseFMN ReductaseIroncell-type evolutionchoanoflagellatecytochrome b561iron colloidmarine microeukaryote

Identifiers

PMID40008892
PMCPMC11934334

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.