Evidence map›Paper›PMID 40008882›Full record

ArticlemSphere2025

Antibodies with specificity to glycan motifs that decorate OMV cargo proteins.

Hyun Young Kim, Christina M Rothenberger, Mary E Davey, Manda Yu

Abstract read
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hyun Young KimDepartment of Microbiology, ADA Forsyth Institute, Cambridge, Massachusetts, USA.
Christina M RothenbergerDepartment of Microbiology, ADA Forsyth Institute, Cambridge, Massachusetts, USA.
Mary E DaveyDepartment of Microbiology, ADA Forsyth Institute, Cambridge, Massachusetts, USA.ORCID 0000-0001-8129-0537
Manda YuDepartment of Microbiology, ADA Forsyth Institute, Cambridge, Massachusetts, USA.ORCID 0000-0001-5932-9597

Funding

Regulatory Mechanisms Controlling Expression of P. gingivalis Surface StructuresR01DE019117 · NIDCR · UNIVERSITY OF FLORIDA · PI DAVEY, MARY ELLEN · 2009 to 2019
$4.5M
L-Arg Availability Affects the Physiological State of Porphyromonas gingivalisR01DE024580 · NIDCR · UNIVERSITY OF FLORIDA · PI DAVEY, MARY ELLEN · 2015 to 2024
$3.5M
Microbial sphingolipids and suppression of host inflammation in periodontal diseaseR01DE031159 · NIDCR · UNIVERSITY OF FLORIDA · PI DAVEY, MARY ELLEN, GIBSON, FRANK C · 2021 to 2025
$2.9M
Regulatory Mechanisms Controlling P. gingivalis Surface StructuresR01DE033659 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI Mary Ellen Davey · 2024 to 2026
$1.7M
Investigating the Function of Fimbriae-forming Lipoprotein in Porphyromonas gingivalisF31DE033227 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI ROTHENBERGER, CHRISTINA · 2023 to 2025
$56k
HHS | NIH | National Institute of Dental and Craniofacial Research (NIDCR) F31DE033227HHS | NIH | National Institute of Dental and Craniofacial Research (NIDCR) R01DE031159HHS | NIH | National Institute of Dental and Craniofacial Research (NIDCR) R01DE033659National Research Foundation of Korea (NRF) NRF-2022R1C1C2007752NIDCR NIH HHS F31 DE033227NIDCR NIH HHS R01 DE019117NIDCR NIH HHS R01 DE024580NIDCR NIH HHS R01 DE031159NIDCR NIH HHS R01 DE033659
6 · The paper itself

Abstract

IMPORTANCE: O-glycosylation of cell surface proteins by bacteria is known to play a role in various functions including colonization and immune evasion. This study highlights the identification of IgM antibodies that specifically recognize O-glycosylated proteins that are selectively carried on outer membrane vesicles (OMVs). The findings suggest a potential host evasion mechanism and open new avenues for using OMVs in vaccine development and targeting O-glycans with antibodies as a therapeutic strategy against the subgingival pathobiont

Indexed as

Antibodies, BacterialAntibody SpecificityBacterial Outer Membrane ProteinsImmunoglobulin MPolysaccharidesPorphyromonas gingivalisAnimalsGlycosylationHumansImmune EvasionAntibodies, BacterialBacterial Outer Membrane ProteinsImmunoglobulin MPolysaccharidesIgM antibodiesO-glycosylationOMVPG1881P. gingivalis

Identifiers

PMID40008882
PMCPMC11934327

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.