ArticlePM & R : the journal of injury, function, and rehabilitation2025
Prevalence of function-limiting late effects in survivors of head and neck cancer.
Article in PM & R : the journal of injury, function, and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Article
- Moderate-to-good acceptability of smartwatch monitoring in head and neck cancer survivors: findings from the MOVE-1 feasibility study.Frontiers in oncology · 2026Article
- Article
- Article
- Prevalence of function-limiting late effects in survivors of head and neck cancer.PM & R : the journal of injury, function, and rehabilitation · 2025Article
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2 authors.
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Abstract
backgroundSurvivors of head and neck cancer (HNC) are commonly affected by multiple complex and interrelated long-term and late effects that can adversely affect their function and quality of life.
objectiveTo define the prevalence of neuromuscular, musculoskeletal, visceral, oncologic, and other late effects affecting function and quality of life in survivors of HNC.
designRetrospective cohort analysis.
settingOutpatient cancer rehabilitation clinic at a physical medicine and rehabilitation hospital that includes a freestanding inpatient rehabilitation unit along with an outpatient clinic.
participantsOne hundred thirty survivors of HNC who sought specialized cancer rehabilitation services to address complex functional impairments.
interventionsNot applicable.
main outcome measuresPrevalence of neuromuscular, musculoskeletal, visceral, oncologic, and other late effects affecting function and quality of life in survivors of HNC.
resultsThe majority underwent surgery (53.8%), chemotherapy (22.3%), and radiation therapy (93.8%) as part of their treatment. Neuromuscular complications such as myelopathy (45.4%), radiculoplexopathy (58.5%), mononeuropathy (84.6%), and myopathy (57.7%) were prevalent. Musculoskeletal impairments included dysphagia (92.3%), dysarthria (60.8%), trismus (40.8%), cervical dystonia (47.7%), and shoulder dysfunction (27.7%). Visceral disorders encompassed lymphedema (86.2%), hypothyroidism (26.2%), and baroreceptor failure (19.2%). Additionally, oncologic complications, including recurrence (18.5%), metastasis (5.4%), and secondary malignancies (8.5%) were observed. Pain (74.6%) and fatigue (31.5%) were reported as major function-limiting impairments. Most survivors (96.9%) were referred to therapy including physical therapy (85.4%), occupational therapy (13.1%), speech-language pathology (84.6%), and lymphedema therapy (72.3%). Most (85.4%) required two or more therapy disciplines.
conclusionSurvivors of HNC accessing cancer rehabilitation services commonly present with diverse, complex, and interrelated neuromuscular, musculoskeletal, visceral, and oncologic late effects that can severely affect function and quality of life. Comprehensive rehabilitation should include evaluation and management of these complex and interrelated late effects by a rehabilitation team that includes cancer rehabilitation physicians, physical therapists, occupational therapists, lymphedema therapists, and speech-language pathologists, among others.
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