ArticleJournal of veterinary internal medicine
Association of Serum Symmetric Dimethylarginine Concentrations and Inflammation in Cats.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- 2026 iCatCare consensus guidelines on the diagnosis and management of chronic kidney disease in cats.Journal of feline medicine and surgery · 2026Guideline
- Longitudinal evaluation of discordant symmetric dimethylarginine and creatinine as markers of glomerular filtration rate in radioiodine-treated hyperthyroid cats.Journal of feline medicine and surgery · 2026Article
- Association Between Serum Symmetric Dimethylarginine and Tooth Resorption in Cats: An Exploratory Study on the Oral-Renal Axis.Veterinary sciences · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundSerum symmetric dimethylarginine (SDMA) concentrations are higher in some hyperthyroid cats with normal renal function, presumably due to increased protein catabolism.
objectivesTo investigate if SDMA is higher in cats with inflammation (defined as elevated serum amyloid A [SAA]). ANIMALS: Twenty-eight cats: 12 with elevated SAA concentrations (> 3.9 μg/mL) and 16 with normal SAA.
methodsRetrospective case control study. Cats presenting to a referral institution between 2016 and 2022 with a documented SAA were identified. Individuals with renal and extrarenal factors known to affect SDMA were excluded. SDMA was measured from stored serum samples. Comparisons were made using the Mann-Whitney U test, and correlations assessed using Spearman's correlation coefficient. Data are presented as median [minimum-maximum].
resultsSDMA was not significantly different between cats with elevated SAA and normal SAA (11 [5-17] μg/dL vs. 13 [9-21] μg/dL, respectively; p = 0.28). There was no correlation between SDMA and SAA (r CONCLUSIONS AND CLINICAL IMPORTANCE: SDMA might be a more representative biomarker of GFR during inflammatory states, provided other confounding factors that affect SDMA are eliminated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.