Evidence map›Paper›PMID 40008526›Full record

ArticleJournal of applied clinical medical physics2025

Characterization of a prototype rapid kilovoltage x-ray image guidance system designed for a linear accelerator radiation therapy unit.

Theodore Arsenault, Jonathan Arrue, Kenneth Gregg, Atallah Baydoun, Atefeh Rezai, Christian Langmack, Lauren Henke, Daniel E Spratt, Rojano Kashani, Alex Price

Abstract read
In one paragraph

Article in Journal of applied clinical medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Theodore ArsenaultDepartment of Radiation Oncology, University Hospitals Seidman Cancer Center, Cleveland, Ohio, USA.ORCID https://orcid.org/0009-0005-2740-5934
Jonathan ArrueDepartment of Radiation Oncology, University Hospitals Seidman Cancer Center, Cleveland, Ohio, USA.
Kenneth GreggDepartment of Radiation Oncology, University Hospitals Seidman Cancer Center, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0002-4831-3714
Atallah BaydounDepartment of Radiation Oncology, University Hospitals Seidman Cancer Center, Cleveland, Ohio, USA.
Atefeh RezaiDepartment of Radiation Oncology, University Hospitals Seidman Cancer Center, Cleveland, Ohio, USA.
Christian LangmackDepartment of Radiation Oncology, University Hospitals Seidman Cancer Center, Cleveland, Ohio, USA.
Lauren HenkeDepartment of Radiation Oncology, University Hospitals Seidman Cancer Center, Cleveland, Ohio, USA.
Daniel E SprattDepartment of Radiation Oncology, University Hospitals Seidman Cancer Center, Cleveland, Ohio, USA.
Rojano KashaniDepartment of Radiation Oncology, University Hospitals Seidman Cancer Center, Cleveland, Ohio, USA.
Alex PriceDepartment of Radiation Oncology, University Hospitals Seidman Cancer Center, Cleveland, Ohio, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study evaluates a novel cone-beam computed tomography (CBCT) imaging solution integrated onto a conventional C-arm linear accelerator (linac) with increased gantry speed. The purpose is to assess the impact of improved imaging hardware and reconstruction algorithms on image quality.

methodsHypersight-CBCT (HS-CBCT) system was compared with the original system (OG-CBCT) on a TrueBeam linac. Performance tests included mechanical, geometric, setup accuracy, and image quality assessment. Image quality metrics were evaluated using conventional CBCT reconstruction and advanced iterative reconstruction (iCBCT), fast iCBCT, and iCBCT with metal artifact reduction. Dosimetry measurements were acquired.

resultsThe HS-CBCT system acquired images in 24.0-44.0s (half trajectory/full trajectory), faster than the OG-CBCT system's acquisition time of 33.5-60.5s (half trajectory/full trajectory). The HS-CBCT system's faster gantry speed resulted in comparable image quality to the OG-CBCT. It improved high-contrast resolution, modulation transfer function, and low-contrast visibility. The faster gantry speed also produced lower radiation doses. The system's uniformity and resolution also improved, particularly with full-fan acquisition techniques.

conclusionThe novel HS-CBCT system on a conventional C-arm linac exhibits superior imaging capabilities compared to the OG-CBCT. Faster gantry speed, larger imaging area, and advanced reconstruction algorithms contribute to enhanced image quality and reduced dose. The study provides comprehensive insights into the new system's performance, serving as a benchmark for future linac installations and highlighting potential benefits in clinical applications. Further investigations are suggested for 4D acquisitions and long-term machine performance.

Indexed as

AlgorithmsCone-Beam Computed TomographyImage Processing, Computer-AssistedNeoplasmsParticle AcceleratorsPhantoms, ImagingRadiotherapy, Image-GuidedRadiotherapy Planning, Computer-AssistedHumansRadiotherapy DosageRadiotherapy, Intensity-Modulatedfast Cone‐Beam CTKV‐IGRTquality assurance

Identifiers

PMID40008526
PMCPMC12059271

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.