ArticleJournal of the American Heart Association2025
Suboptimal Control of Small Dense Low-Density Lipoprotein Cholesterol Is Associated With Coronary Plaque Progression: An Intravascular Ultrasound Study.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Impact of kimura-takemoto atrophy classification on first-lineFrontiers in medicine · 2026Article
- Pericoronary adipose tissue inflammation mediates the atherogenic effects of lipids on multivessel coronary artery disease: a CCTA-based radiomics analysis.Frontiers in cardiovascular medicine · 2025Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlaque progression (PP) is critical between subclinical atherosclerosis and plaque rupture. Small dense low-density lipoprotein cholesterol (sdLDL-C) is considered as the most atherogenic lipoprotein. This study aims to investigate the relationship between sdLDL-C level and PP in patients with stable coronary artery disease.
methodsWe conducted a retrospective analysis of 146 lesions in 86 patients by repeat intravascular ultrasound examinations from January 2020 to May 2023. PP was determined by increases in percent atheroma volume, defined as the atheroma volume in proportion to the volume occupied by the entire vascular wall, ≥5% during follow-up. Time-averaged values were calculated for all cardiometabolic parameters including sdLDL-C. Multivariate logistic regression analysis was performed to interrogate the association between time-averaged sdLDL-C and PP.
resultsDuring a median follow-up of 12.6 months, PP was found in 65 lesions (44.5%), and mean changes in percent atheroma volume were 4.1%±10.2%. A positive correlation was observed between time-averaged sdLDL-C and changes in total atheroma volume (Pearson
conclusionsOur findings suggest that sdLDL-C is an independent risk factor of PP in patients with coronary artery disease. Intensive control of sdLDL-C along with other risk factors should be considered to mitigate PP and improve cardiovascular outcomes.
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