SynthesisPsychological medicine2025
Resting-state network alterations in depression: a comprehensive meta-analysis of functional connectivity.
Synthesis in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 8 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Multilevel Mechanisms and Clinical Efficacy of Psilocybin in Depression Treatment: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Shared genetic underpinnings of gray matter volume alterations and metabolic traits in major depressive disorder.BMC psychiatry · 2026Pooled it
- Research trends and knowledge mapping of transcranial direct current stimulation in depression: a bibliometric study based on web of science, Scopus, and PubMed (2000-2025).Frontiers in psychiatry · 2026Pooled it
- Alterations in resting-state brain activity patterns following antidepressant treatment: insights from a coordinate-based meta-analysis.Psychological medicine · 2025Pooled it
- The lifespan trajectories of brain activities related to conflict-driven cognitive control.Science bulletin · 2025Pooled it
- From risk to chronicity: genetic and neuroimaging insights into the evolving patterns of spontaneous brain activity in schizophrenia.Psychological medicine · 2025Pooled it
- Shared neuroimaging and molecular profiles in type 2 diabetes mellitus and major depressive disorder: an integrative analysis of genetic, transcriptomic, and neuroimaging data.Translational psychiatry · 2025Pooled it
- Resting-State Brain Activity Changes and Their Genetic Correlates in Mild Traumatic Brain Injury.Human brain mapping · 2025Pooled it
- Ketamine's impact on rumination-related brain dynamics: insights from a randomized controlled fMRI trial.Translational psychiatry · 2026Trial
- Suicidal ideation and cognitive function: a comparative study in adolescents with unipolar versus bipolar depression.European archives of psychiatry and clinical neuroscience · 2026Article
- Edge-centric brain connectomes reveal two molecularly distinct neurobiological subtypes of adolescent major depressive disorder.European child & adolescent psychiatry · 2026Article
- Article
- Increased beta-band salience network connectivity predicts 12-month longitudinal changes in depressive and anxiety symptom severity in young adults: a resting-state EEG study.European archives of psychiatry and clinical neuroscience · 2026Article
- Changes in resting-state functional connectivity linked to affective symptoms: insights from a population-based study of adolescents and young adults.Translational psychiatry · 2026Article
- Targeting mechanisms of change as a path to precision psychotherapy for community settings.Psychotherapy research : journal of the Society for Psychotherapy Research · 2026Article
- HARMONY: A large-scale harmonized neuroimaging dataset for research on anxious misery disorders.bioRxiv : the preprint server for biology · 2026Article
- Cell-type and spatiotemporal transcriptional signatures of white matter morphometric similarity network alterations in major depressive disorder.Psychological medicine · 2026Article
- Brain network centrality following stress in adults with major depressive disorder and childhood trauma.Neurobiology of stress · 2026Article
- Insomnia severity impact dynamic connectivity and modulate connectivity-cognitive links in major depressive disorder.Psychological medicine · 2026Article
- Altered Dynamic Functional Connectivity of the Frontoparietal Network in Major Depressive Disorder: Evidence From a Large-Scale Resting-State fMRI Study.Brain and behavior · 2026Article
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDepression has been linked to disruptions in resting-state networks (RSNs). However, inconsistent findings on RSN disruptions, with variations in reported connectivity within and between RSNs, complicate the understanding of the neurobiological mechanisms underlying depression.
methodsA systematic literature search of PubMed and Web of Science identified studies that employed resting-state functional magnetic resonance imaging (fMRI) to explore RSN changes in depression. Studies using seed-based functional connectivity analysis or independent component analysis were included, and coordinate-based meta-analyses were performed to evaluate alterations in RSN connectivity both within and between networks.
resultsA total of 58 studies were included, comprising 2321 patients with depression and 2197 healthy controls. The meta-analysis revealed significant alterations in RSN connectivity, both within and between networks, in patients with depression compared with healthy controls. Specifically, within-network changes included both increased and decreased connectivity in the default mode network (DMN) and increased connectivity in the frontoparietal network (FPN). Between-network findings showed increased DMN-FPN and limbic network (LN)-DMN connectivity, decreased DMN-somatomotor network and LN-FPN connectivity, and varied ventral attention network (VAN)-dorsal attentional network (DAN) connectivity. Additionally, a positive correlation was found between illness duration and increased connectivity between the VAN and DAN.
conclusionsThese findings not only provide a comprehensive characterization of RSN disruptions in depression but also enhance our understanding of the neurobiological mechanisms underlying depression.
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