Evidence map›Paper›PMID 40008332›Full record

ArticleBrain communications2025

Exploratory analysis of biological age measures in a remyelination clinical trial.

Christopher E McMurran, Ermelinda de Meo, Nick G Cunniffe, J William L Brown, Ferran Prados, Baris Kanber, James H Cole, Alasdair J Coles, Sara Hägg, Declan T Chard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Regional brain aging patterns reveal disease-specific pathways of neurodegeneration.medRxiv : the preprint server for health sciences · 2025
    Article
  5. When Age Is More Than a Number: Acceleration of Brain Aging in Neurodegenerative Diseases.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christopher E McMurranDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0AH, UK.ORCID https://orcid.org/0000-0002-8710-0930
Ermelinda de MeoDepartment of Neuroinflammation, NMR Research Unit, Queen Square Multiple Sclerosis Centre, University College London (UCL) Queen Square Institute of Neurology, London, WC1B 5EH, UK.ORCID https://orcid.org/0000-0001-5531-1111
Nick G CunniffeDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0AH, UK.ORCID https://orcid.org/0000-0002-7562-2838
J William L BrownDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0AH, UK.ORCID https://orcid.org/0000-0002-7737-5834
Ferran PradosDepartment of Neuroinflammation, NMR Research Unit, Queen Square Multiple Sclerosis Centre, University College London (UCL) Queen Square Institute of Neurology, London, WC1B 5EH, UK.ORCID https://orcid.org/0000-0002-7872-0142
Baris KanberDepartment of Neuroinflammation, NMR Research Unit, Queen Square Multiple Sclerosis Centre, University College London (UCL) Queen Square Institute of Neurology, London, WC1B 5EH, UK.ORCID https://orcid.org/0000-0003-2443-8800
James H ColeDepartment of Computer Science, Centre for Medical Image Computing, University College London, London, WC1V 6LJ, UK.ORCID https://orcid.org/0000-0003-1908-5588
Alasdair J ColesDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0AH, UK.ORCID https://orcid.org/0000-0003-4738-0760
Sara HäggDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-171 77, Sweden.ORCID https://orcid.org/0000-0002-2452-1500
Declan T ChardDepartment of Neuroinflammation, NMR Research Unit, Queen Square Multiple Sclerosis Centre, University College London (UCL) Queen Square Institute of Neurology, London, WC1B 5EH, UK.ORCID https://orcid.org/0000-0003-3076-2682

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enhancing CNS myelin repair (remyelination) is a promising strategy to prevent neurodegeneration and associated progressive disability in multiple sclerosis. Remyelination becomes inefficient with older chronological age, but the relationship between measures of biological age and remyelination has not been previously described in a clinical cohort. Here, we investigated two measures of biological age amongst participants of the Cambridge Centre for Myelin Repair One trial of bexarotene: MRI brain age (BA

Indexed as

biological agebrain ageclinical trialMRIremyelination

Identifiers

PMID40008332
PMCPMC11852336

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.