Evidence map›Paper›PMID 40008296›Full record

ArticleNature machine intelligence2025

Deep learning enhances the prediction of HLA class I-presented CD8

Jeremy Wohlwend, Anusha Nathan, Nitan Shalon, Charles R Crain, Rhoda Tano-Menka, Benjamin Goldberg, Emma Richards, Gaurav D Gaiha, Regina Barzilay

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature machine intelligence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jeremy Wohlwend *Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA USA.
Anusha Nathan *Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA USA.
Nitan ShalonDepartment of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA USA.
Charles R CrainRagon Institute of Mass General, MIT and Harvard, Cambridge, MA USA.
Rhoda Tano-MenkaRagon Institute of Mass General, MIT and Harvard, Cambridge, MA USA.
Benjamin GoldbergRagon Institute of Mass General, MIT and Harvard, Cambridge, MA USA.ORCID 0009-0007-0403-6181
Emma RichardsRagon Institute of Mass General, MIT and Harvard, Cambridge, MA USA.
Gaurav D GaihaRagon Institute of Mass General, MIT and Harvard, Cambridge, MA USA.ORCID 0000-0001-6875-4472
Regina BarzilayDepartment of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA USA.

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
Bill & Melinda Gates Foundation INV-027454NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM144273
6 · The paper itself

Abstract

Accurate in silico determination of CD8

Indexed as

Antigen presentationMHC class I

Identifiers

PMID40008296
PMCPMC11847706

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.