Evidence map›Paper›PMID 40008279›Full record

ArticlePhysics and imaging in radiation oncology2025

Synthetic Computed Tomography generation using deep-learning for female pelvic radiotherapy planning.

Rachael Tulip, Sebastian Andersson, Robert Chuter, Spyros Manolopoulos

Abstract read
In one paragraph

Article in Physics and imaging in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Deep Learning for CT Synthesis in Radiotherapy.Bioengineering (Basel, Switzerland) · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rachael TulipNorthern Centre for Cancer Care - North Cumbria, Newcastle upon Tyne Hospitals NHS Foundation Trust, Carlisle, Cumbria CA2 7HY, UK.
Sebastian AnderssonRaySearch Laboratories, Stockholm, Sweden.
Robert ChuterChristie Medical Physics and Engineering (CMPE), The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK.
Spyros ManolopoulosNorthern Centre for Cancer Care - North Cumbria, Newcastle upon Tyne Hospitals NHS Foundation Trust, Carlisle, Cumbria CA2 7HY, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthetic Computed Tomography (sCT) is required to provide electron density information for MR-only radiotherapy. Deep-learning (DL) methods for sCT generation show improved dose congruence over other sCT generation methods (e.g. bulk density). Using 30 female pelvis datasets to train a cycleGAN-inspired DL model, this study found mean dose differences between a deformed planning CT (dCT) and sCT were 0.2 % (D98 %). Three Dimensional Gamma analysis showed a mean of 90.4 % at 1 %/1mm. This study showed accurate sCTs (dose) can be generated from routinely available T2 spin echo sequences without the need for additional specialist sequences.

Indexed as

Dose validationMR-onlySynthetic CT

Identifiers

PMID40008279
PMCPMC11851199

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.