ArticleERJ open research2025
OSA symptom subtypes and hypoxic burden independently predict distinct cardiovascular outcomes.
Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Which nocturnal hypoxemia parameters are associated with ambulatory blood pressure monitoring in adults with obstructive sleep apnea? A systematic review.Sleep & breathing = Schlaf & Atmung · 2026Pooled it
- Oxidative and Inflammatory Mechanisms Induced by Intermittent Hypoxia Leading to Vascular Alterations in Rodents: A Systematic Review and Meta-Analysis.Oxidative medicine and cellular longevity · 2026Pooled it
- Sex-specific OSAS phenotypes require outcome-oriented modelling and data validation.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Hypoxic burden reduction after lateral pharyngoplasty in patients with obstructive sleep apnea: Beyond the apnea-hypopnea index.Sleep & breathing = Schlaf & Atmung · 2026Observational
- Review
- Associations of excessive sleepiness with sleep apnea physiological endo-phenotypes: the multi-ethnic study of atherosclerosis.Annals of the American Thoracic Society · 2026Article
- Obstructive Sleep Apnea and Coronary Artery Disease: An Overlooked Cardiovascular Risk Factor.Biomedicines · 2026Review
- Impact of obstructive lung disease and sleep apnea symptoms on cardiovascular risk and all-cause mortality: insights from a community-dwelling cohort.Sleep & breathing = Schlaf & Atmung · 2026Article
- Advances in cardiovascular risk assessment indicators in obstructive sleep apnea.Frontiers in public health · 2026Review
- Effect Heterogeneity of CPAP on MACE by Nocturnal Hypoxia Burden in Older Adults OSAS: A Propensity Score Matching Study.Clinical interventions in aging · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Study objectives: Studies on obstructive sleep apnoea (OSA) have identified clinically relevant symptom-based subtypes and novel OSA-specific nocturnal hypoxic measures. Both traits are individually associated with cardiovascular outcomes, but evidence about their independent or shared effects is unknown. This study investigated the simultaneous contributions of OSA symptom subtypes and hypoxic burden (HB) on incident cardiovascular outcomes. Methods: Sleep Heart Health Study participants with high-quality oxygen saturation, apnoea-hypopnea index (AHI) and symptom data were included. Participants with OSA (AHI ≥5 events·h Results: 4396 participants free of cardiovascular disease were analysed, with median follow-up >11 years. Higher HB was associated with worse cardiovascular mortality (HR (95% CI): 1.63 (1.13-2.35); p=0.009) independently of symptom subtypes. Compared to those without OSA, the excessively sleepy OSA subtype had higher risk of incident MACE (1.62 (1.23-2.15); p<0.001), independently of HB. Among participants with moderate-severe OSA (AHI ≥15 events·h Conclusion: OSA symptom subtypes and HB are independently associated with MACE and cardiovascular mortality, respectively. Thus, both are important for understanding OSA-related cardiovascular risk. Future studies using clinical samples including OSA therapy information that incorporate symptom subtypes and novel biomarkers, such as HB, could improve predictive models for cardiovascular disease risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.