Evidence map›Paper›PMID 40008126›Full record

ArticleFrontiers in pharmacology2025

Post-treatment of rat aflatoxicosis by camel milk and silymarin.

Nahla H Hassaneen, Shabaan A Hemeda, Abeer F El Nahas, Ghadeer M Albadrani, Muath Q Al-Ghadi, Zuhair M Mohammedsaleh, Sabreen E Fadl, Eman M El-Diasty, Hader I Sakr

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nahla H HassaneenDepartment of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine, Matrouh University, Matrouh, Egypt.
Shabaan A HemedaDepartment of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt.
Abeer F El NahasDepartment of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt.
Ghadeer M AlbadraniDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Muath Q Al-GhadiDepartment of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Zuhair M MohammedsalehDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.
Sabreen E FadlBiochemistry Department, Faculty of Veterinary Medicine, Matrouh University, Matrouh, Egypt.
Eman M El-DiastyMycology Department, Animal Health Research Institute Dokki, Giza (ARC), Giza, Egypt.
Hader I SakrDepartment of Medical Physiology, Faculty of Medicine, Cairo University, Giza, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Aflatoxins are highly potent mycotoxins that can seriously harm the health of humans and a variety of animal species. On the other hand, camel milk and silymarin offer a variety of positive effects for many animal species. In addition, camel milk and silymarin reduce the impact of AFB1 on the hematology, serum biochemical markers, histopathology of the liver and testes, and expression of the inflammatory, antioxidant, and male reproductive genes. Methods: 40 rats were used to evaluate the beneficial effect of silymarin and camel milk against aflatoxin B1 (AFB1) toxicity in rats. The classified treatments were the control negative (no treatment) and the control positive (supplied with 1.4 mg aflatoxin/kg diet) for 28 days. Camel milk group (supplied with 1.4 mg aflatoxin/kg diet) for 28 days and camel milk (1 milliliter of camel milk per kilogram of body weight) orally, from day 29 to day 43). Silymarin (supplied with 1.4 mg aflatoxin/kg diet) for 28 days and silymarin (20 mg silymarin/kg b.wt), orally, from day 29 to day 43). The evaluation was done through measuring leukocyte count, liver function tests, carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), ferritin, and testosterone. Moreover, the histopathology of the liver and testes was done along with expression levels of specific genes in the liver and testes. Results: The outcomes showed that the post-treatment with silymarin and camel milk improved biochemical markers in serum and ability to reproduce. Conclusion: In conclusion, post-treatment with camel milk and silymarin could mitigate the negative effect of AFB1 on rats.

Indexed as

aflatoxin B1camel milkgene expressionpost-treatmentserum biochemistrysilymarin

Identifiers

PMID40008126
PMCPMC11850410

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