Psychiatric Manifestations of Delta-8-Tetrahydrocannabinol (Δ8-THC) Use Among Patients With Preexisting Psychiatric Disorders: A Case Series.

Delta-8-tetrahydrocannabinol (Δ8-THC) products, made from hemp-derived cannabidiol, have become more widely available since changes in legislation allowed hemp to be excluded from controlled substances. These products are often perceived as a safe, legal, and accessible alternative to marijuana or delta-9-tetrahydrocannabinol. However, scientific research on their effects remains limited. There have been reports of psychiatric symptoms associated with Δ8-THC use, although the literature is not yet comprehensive. In this report, we present three cases of patients with distinct preexisting psychiatric disorders who developed various psychiatric manifestations, including psychosis, after using Δ8-THC products. All three individuals had purchased these products legally, believing them to be safe and effective for managing their symptoms. However, their use ultimately led to psychiatric symptoms severe enough to require hospitalization. This case series highlights the need for greater awareness of the potential psychiatric effects of Δ8-THC, particularly among individuals with preexisting mental health conditions, and underscores the critical gap in research on these products.