ArticleCureus2025
Back Pain as a Clue to Spinal Cord Involvement in Sjögren's Syndrome: An Uncommon Case.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sjögren's syndrome (SS) is an autoimmune disease with systemic manifestations. Neurological manifestations of SS include vasculitis, dorsal ganglionitis, demyelination, myelitis, myeloradiculitis, meningoencephalitis, cognitive dysfunction, and autonomic dysfunction mediated by antibodies. We present a case of a 65-year-old woman with a significant medical history of rheumatoid arthritis and secondary Sjögren's syndrome, diagnosed 20 years prior, and treated non-Hodgkin lymphoma. She presented to the emergency department with progressive lower back pain, radiating to the lower limbs for the past five months, along with sensory loss, weakness in the lower limbs, urinary retention, fecal incontinence, and recurrent fever. On examination, she had grade 4 paraparesis predominantly in the proximal muscles, with suspended thermoalgesic sensation from D6-11 and areas of allodynia in L5-S1, abolished deep tendon reflexes in the lower limbs, and absent bilateral plantar reflexes. MRI revealed a longitudinally extensive spinal cord lesion (from D4 to the conus medullaris) with T2 hyperintensity, contrast enhancement, and meningeal and cauda equina root thickening. Lumbar puncture showed lymphocytosis, hypoglycorrhachia, and hyperproteinorrachia, suggestive of lymphocytic meningitis. Microbiology, immunophenotyping, anti-aquaporin-4 antibodies, angiotensin-converting enzyme (ACE), calcium, and urinary calcium levels were normal. Meningeal biopsy at D10 showed an unspecific mononuclear inflammatory process. She received pulses of methylprednisolone but continued to experience paraparesis, fever, asthenia, and new vertebral joint arthritis/synovitis at L4-L5, leading to the initiation of cyclophosphamide treatment with progressive improvement. Sjögren's syndrome has a wide range of manifestations and can involve multiple systems. Spinal cord involvement is rare and presents diagnostic dilemmas between infectious causes, other autoimmune diseases, and neuromyelitis optica spectrum disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.