ArticleAnnals of Ibadan postgraduate medicine2024
LEVEL OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) AND PATTERN OF INJURIES IN POLYTRAUMA PATIENTS.
Article in Annals of Ibadan postgraduate medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Trauma and trauma-related injuries are rife worldwide and constitutes part of the most common cause of hospital admission. Monocyte Chemoattractant Protein-1 is produced by several array of cells in acute traumatic injury and tissue repair. Materials and Method: This research is a prospective hospital-based study carried out at a tertiary hospital in south western Nigeria. Patients admitted through the Emergency department were categorized based on the inclusion criteria. Those eligible for inclusion were recruited and had their blood samples taken into an endotoxin free test tube at 48 +/- 2 hours after trauma. MCP-1 levels in the serum was estimated though the Human MCP-1 ELISA kit. This process was carried out using the ELISA technique based on the manufacturer's guide. Results: The samples of 110 patients were analyzed, patient with the highest combination of injury had injuries to the Head and Neck, Face, chest, Abdomen, Extremity fractures and skin with MCP-1 value of 463pg/ml. The test of relationship using the F-test (0.299), and P-value (1.000) does not demonstrate any correlation between patterns of injury to MCP-1 values in polytrauma patients. Conclusion: The study showed no significant relationship between the patterns of injury in polytrauma patients with serum MCP-1 levels. Therefore, injury pattern cannot be used to predict MCP-1 levels.
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40007704PMC11848364What OpenQuestion holds
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