ArticleFrontiers in aging neuroscience2025
Improved early postoperative cognition in elderly gastrointestinal patients: a randomized controlled trial on the role of ultrasound-guided stellate ganglion block.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of stellate ganglion block on postoperative sleep disturbance: a systematic review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2026Pooled it
- Effect of intraoperative Electroencephalogram-guided anesthesia on postoperative cognitive function in elderly patients: a systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials.BMC anesthesiology · 2025Pooled it
- Application of stellate ganglion modulation in mental disorders and the future prospects of physical therapies.Fundamental research · 2026Review
- Perioperative Sympathetic Blockade: Mechanisms and Clinical Advances in Sensory Processing Modulation - A Narrative Review.Journal of pain research · 2026Review
- Effects of stellate ganglion block anesthesia on cognition and biomarkers in patients undergoing gastrointestinal surgery.World journal of gastrointestinal surgery · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
Background: This study evaluates the impact of ultrasound-guided stellate ganglion block (SGB) on early postoperative cognitive dysfunction (POCD) in elderly patients who underwent laparoscopic gastrointestinal (GI) surgery, as well as its potential effect on oxidative stress and inflammatory responses. Methods: In this randomized controlled trial, 104 elderly patients scheduled for elective laparoscopic GI surgery were randomized to receive ultrasound-guided SGB before general anesthesia (SGB group) or general anesthesia alone (control group). A total of 98 patients completed the study. Cognitive function was assessed using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) preoperatively, and on postoperative days one and three. The perioperative recordings included mean arterial pressure, heart rate, and the bispectral index. Blood samples were analyzed for interleukin-6 (IL-6), superoxide dismutase (SOD), and malondialdehyde (MDA). Results: The SGB group had a significantly lower incidence of POCD on postoperative day one ( Conclusion: Preoperative SGB reduces early POCD in elderly patients who undergo laparoscopic GI surgery, possibly through the inhibition of oxidative stress and inflammatory responses.
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