ArticleFrontiers in cellular and infection microbiology2025
Distinct vaginal microbiome and metabolome profiles in women with preterm delivery following cervical cerclage.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The vaginal microbiome in pregnancy and preterm birth: mechanisms, disparities, and therapeutic opportunities.NPJ biofilms and microbiomes · 2026Review
- Dynamic serum metabolomic changes during Chinese herbal hot compress therapy for postpartum uterine involution: pathway analysis and candidate biomarker identification.Frontiers in medicine · 2026Article
- Characteristics of the vaginal microbiota associated with recurrent spontaneous preterm birth: a prospective cohort study.Journal of translational medicine · 2025Article
- Comprehensive analysis of vaginal microbiota, metabolites, and inflammatory factors in preterm and term pregnancies.Frontiers in microbiology · 2025Article
- Microbiome-based therapeutics for metabolic disorders: harnessing microbial intrusions for treatment.Frontiers in medical technology · 2025Review
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Authors and funding
8 authors.
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Abstract
Preterm birth (PTB) is a major cause of infant morbidity and mortality. The aim of this study was to investigate the effect of vaginal microbiota and metabolites on the outcome of pregnant women. In this study, a total of 127 pregnant women provided written informed consent prior to enrollment in accordance with the approved institutional guidelines, but only 45 pregnancies met the experimental requirements, and then blood and cervical vaginal fluid (CVF) samples were collected before delivery (at the second week after cervical cerclage). Pregnant women with PTB exhibited high white blood cell and neutrophil contents, high neutrophil-to-lymphocyte ratio (NLR), and high systemic inflammation response index (SIRI) in the blood. Vaginal microbiome revealed that the proportion of beneficial bacteria (including
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