Evidence map›Paper›PMID 40007602›Full record

ArticleProceedings of SPIE--the International Society for Optical Engineering2020

Novel Intra-Operative Peripheral Nerve Agent for Fluorescence Guided Imaging.

Xiang Liu, Paul Lovell, Denzel Ryan Cruz, Lucas Houser, Chad A LaGrange, Aaron M Mohs

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of SPIE--the International Society for Optical Engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiang LiuDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Paul LovellDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Denzel Ryan CruzUniversity of Illinois at Urbana- Champaign, Champaign, IL 61820, USA.
Lucas HouserDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Chad A LaGrangeFred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Aaron M MohsDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Funding

Nonclinical development of Nervelight, an intra-operative peripheral nerve imaging agentR44CA180745 · NCI · MANZANITA PHARMACEUTICALS, INC. · PI KAHL, STEPHEN B · 2017 to 2018
$2.0M
NCI NIH HHS R44 CA180745
6 · The paper itself

Abstract

Nerve injuries that significantly affect a patient's quality of life are a common complication of major surgeries. Fluorescence-guided surgery (FGS) has become increasingly popular because it allows physicians to position their instruments precisely during surgeries to spare nerves, for example, in radical prostatectomies. Visualization of nerves during oncological surgeries is an unmet clinical need that is under investigation. Here, we address this unmet need with a contrast agent that is selective for peripheral nerves. Our contrast agent combines an existing near infrared (NIR) dye that fluoresces in the 800 region with a naturally-occurring protein of the human nervous system, nerve growth factor (NGF) - a combination termed Nervelight

Indexed as

Fluorescence-guided imagingNervelight™nerve sparing

Identifiers

PMID40007602
PMCPMC11853179

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.