ArticleFrontiers in human neuroscience2024
Diagnostic ultrasound enhances, then reduces, exogenously induced brain activity of mice.
Article in Frontiers in human neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Transcranially delivered diagnostic ultrasound (tDUS) applied to the human brain can modulate those brains such that they became more receptive to external stimulation relative to sham ultrasound exposure. Here, we sought to directly measure the effect of tDUS on mouse brain activity subjected to an external stimulation-a blinking light. Using electrocorticography, we observed a substantial increase in median brain activity due to tDUS plus a blinking light relative to baseline and relative to sham tDUS plus a blinking light. Subsequent brain activity decreased after cessation of tDUS but with continuation of the blinking light, though it remained above that demonstrated by mice exposed to only a blinking light. In a separate experiment, we showed that tDUS alone, without a blinking light, had no observable effect on median brain activity, but upon its cessation, brain activity decreased. These results demonstrate that
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