ArticleScientifica2025
Phytochemical Profiling and Toxicity Assessment of Aqueous Extract From Bitter Apricot Kernels Cultivated in Morocco.
Article in Scientifica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Mineral Composition, Physicochemical Characteristics, and Antioxidant and Antibacterial Properties of Oil Extracted From Moroccan Bitter Apricot Kernels.Scientifica · 2026Article
- Acute and subacute toxicity evaluation of ZhenzhuXiaoji decoction in preclinical models: implications for safe clinical use.Frontiers in pharmacology · 2025Article
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Authors and funding
7 authors.
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Abstract
Apricot kernels contain amygdalin, a cyanogenic glycoside that degrades to cyanide upon chewing or crushing, posing a potential toxicity risk to humans. The present study aimed to determine the phenolic compounds and to evaluate the subacute and acute toxicity of the aqueous extract of bitter apricot kernels (BAKs) in Swiss albino mice. The chemical characterization was carried out with HPLC-DAD analyses, and acute toxicity was done by extract's oral administration once for 72-h period at doses of 500-6000 mg/kg body weight (bw). For the subacute toxicity, mice were administrated orally by repeated doses of 100, 500, and 1000 mg/kg bw for 28 days. The hematological, biochemical parameters and the histological examinations of vital organs (kidney, liver, and spleen) were done by sacrificing the animals after the subacute toxicity period. The results revealed 11 phenolic compounds with a total of 61 mg/g of extract. In the acute toxicity study, no signs of toxicity or mortality were observed during the experiment period, and the LD
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