Evidence map›Paper›PMID 40007463›Full record

ArticleJournal of chemical information and modeling2025

Structure-Based Identification of Non-covalent Prolyl Oligopeptidase 80 Inhibitors Targeting

Vinícius Alexandre Fiaia Costa, Flávia Nader Motta, Alexandra Maria Dos Santos Carvalho, Felipe da Silva Mendonça de Melo, Melina Mottin, Sébastien Charneau, Philippe Grellier, Jaime Martins Santana, Izabela Marques Dourado Bastos, Bruno Junior Neves

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of chemical information and modeling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vinícius Alexandre Fiaia CostaLaboratory of Cheminformatics, Faculty of Pharmacy, Federal University of Goiás, Goiânia 74605-170, Brazil.ORCID 0000-0001-6479-5963
Flávia Nader MottaPathogen-Host Interface Laboratory, Department of Cell Biology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil.
Alexandra Maria Dos Santos CarvalhoPathogen-Host Interface Laboratory, Department of Cell Biology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil.
Felipe da Silva Mendonça de MeloPathogen-Host Interface Laboratory, Department of Cell Biology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil.
Melina MottinPathogen-Host Interface Laboratory, Department of Cell Biology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil.
Sébastien CharneauLaboratory of Biochemistry and Protein Chemistry, Department of Cell Biology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil.
Philippe GrellierUMR, Molécules de Communication et Adaptation des Micro-organismes, Muséum National d'Histoire Naturelle, Équipe Parasites et Protistes Libres, 7245 Paris, France.
Jaime Martins SantanaPathogen-Host Interface Laboratory, Department of Cell Biology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil.
Izabela Marques Dourado BastosPathogen-Host Interface Laboratory, Department of Cell Biology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil.
Bruno Junior NevesLaboratory of Cheminformatics, Faculty of Pharmacy, Federal University of Goiás, Goiânia 74605-170, Brazil.ORCID 0000-0002-1309-8743

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chagas disease remains a persistent public health challenge due to the limited efficacy and significant toxicity of current pharmacological treatments. This highlights the urgent need for novel drugs with innovative mechanisms of action, specifically targeting cell infection pathways. The prolyl oligopeptidase of

Indexed as

Protozoan ProteinsSerine EndopeptidasesSerine Proteinase InhibitorsTrypanocidal AgentsTrypanosoma cruziChagas DiseaseHumansMolecular Docking SimulationProlyl OligopeptidasesStructure-Activity RelationshipProlyl OligopeptidasesProtozoan ProteinsSerine EndopeptidasesSerine Proteinase InhibitorsTrypanocidal Agents

Identifiers

PMID40007463
PMCPMC11898053

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.