ReviewThe New phytologist2025
Breaking into nature's secret medicine cabinet: lichens - a biochemical goldmine ready for discovery.
Review in The New phytologist, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Lichen-Derived Bioactive Compounds in Diabetes and Cardiovascular Risk: Experimental Evidence, Mechanisms, and Translational Challenges.Biomedicines · 2026Review
- Helitrons are enriched in lichenized fungi with long generation lengths and small distribution sizes.G3 (Bethesda, Md.) · 2026Article
- Antifungal and Profungal Potentials of Acetone-Extracted Complexes of Lichen Substances on MacromyceteMolecules (Basel, Switzerland) · 2026Article
- Tracing the origins of crmA megasynthase through lichen genomes.Current biology : CB · 2026Article
- Complex multicellularity is linked with expanded specialized metabolite production in microorganisms.Nature microbiology · 2026Article
- Lichen Extracts Containing Volatile Compounds Induce Oxidative Stress and Modulate the Growth ofInternational journal of molecular sciences · 2026Article
- Deciphering the biosynthetic pathways of lichen acids.The New phytologist · 2026Article
- Functional redundancy and stability support the resilience of the Evernia prunastri holobiont under urbanization.Environmental microbiome · 2026Article
- Review
- ARTS-DB 2.0: an expanded database for target-directed genome mining across bacteria and fungi.Database : the journal of biological databases and curation · 2026Article
- Is the Reindeer LichenMolecules (Basel, Switzerland) · 2026Article
- Paired-omics-based exploration and characterization of biosynthetic diversity in lichenized fungi.Microbial genomics · 2025Article
- Ramalina farinacea mitigates cytogenotoxicity and physiological, biochemical, and anatomical alterations induced by nickel in Allium cepa.Scientific reports · 2025Article
- A Biosynthetic and Taxonomic Atlas of the Global Lichen Holobiont.Environmental microbiology · 2025Article
- Lichens are a treasure chest of bioactive compounds: fact or fake?The New phytologist · 2025Article
- The lichen secondary metabolite lichesterinic acid exhibits antibiofilm activity against fungal pathogens.Frontiers in cellular and infection microbiology · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Secondary metabolites are a crucial source of bioactive compounds playing a key role in the development of new pharmaceuticals. Recently, biosynthetic research has benefited significantly from progress on various fronts, including reduced sequencing costs, improved genome/metabolome mining strategies, and expanding tools/databases to compare and characterize chemical diversity. Steady advances in these fields are crucial for research on non-modal organisms such as lichen-forming fungi (LFF). Although most fungi produce bioactive metabolites, biosynthetic research on LFF (c. 21% of known fungi) lags behind, primarily due to experimental challenges. However, in recent years, several such challenges have been tackled, and, in parallel, a critical foundation of genomic data and pipelines has been established to accomplish the valorization of this potential. Integrating these concurrent advances to accelerate biochemical research in LFF provides a promising opportunity for new discoveries. This review summarizes the following: recent advances in fungal and LFF omics, and chemoinformatics research; studies on LFF biosynthesis, including chemical diversity and evolutionary/phylogenetic aspects; and experimental milestones in LFF biosynthetic gene functions. At the end, we outline a vision and strategy to combine the progress in these research areas to harness the biochemical potential of LFF for pharmaceutical development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.