Evidence map›Paper›PMID 40007211›Full record

ReviewCell transplantation

Research Guideline Recommendations for Research on Stem Cells, Human Embryos, and Gene Editing.

Susanna R Var, Phoebe Strell, Anala Shetty, Alex Roman, Isaac H Clark, Andrew T Crane, Gary L Dunbar, Kyle Fink, Andrew W Grande, Ann M Parr and 6 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Susanna R VarDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-5494-4248
Phoebe StrellDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-1700-015X
Anala ShettyDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0003-1185-3183
Alex RomanDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0003-1500-9764
Isaac H ClarkDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN, USA.
Andrew T CraneDepartment of Medicine, University of Minnesota, Minneapolis, MN, USA.
Gary L DunbarDepartment of Psychology, Central Michigan University, Mount Pleasant, MI, USA.
Kyle FinkDepartment of Neurology, University of California, Davis, Davis, CA, USA.
Andrew W GrandeDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN, USA.
Ann M ParrDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN, USA.
Julien RossignolCollege of Medicine, Central Michigan University, Mount Pleasant, MI, USA.
Paul R SanbergDepartment of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL, USA.
Li-Ru ZhaoDepartment of Neurosurgery, The State University of New York Upstate Medical University, Syracuse, NY, USA.
Layandysha V ZholudevaGladstone Institutes, San Francisco, CA, USA.ORCID 0000-0003-4995-8466
Walter C LowDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-8593-0175
American Society for Neural Therapy and Repair Task Force

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent advances in biomedical technologies have extended the boundaries of previously established regulatory guidelines pertaining to stem cell research. These guidelines constrained the study of human pluripotent stem cells (hPSCs) and their derivatives from use under various conditions, including the introduction of hPSCs into the brains of host animals because of concerns of humanizing the brains of animal species. Other guidelines constrained the use of hPSCs in creating human-animal chimeras because of the potential contribution of human stem cells not only to the brain but also to the germline. Some regulatory guidelines forbid the growing of human embryos

Indexed as

Embryo, MammalianGene EditingStem Cell ResearchAnimalsGuidelines as TopicHumansPluripotent Stem Cellsgene editinghuman–animal chimerashuman embryosmitochondrial replacementstem cellstransplantation

Identifiers

PMID40007211
PMCPMC11863228

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.