Design and Synthesis of 3-(Phenylsulfonamido)benzamide Derivatives as Potent Carbonic Anhydrase IX Inhibitors: Biological Evaluations and Molecular Modeling Studies.

Mohammad A Khanfar, Mohammad Saleh

Abstract read

In one paragraph

Article in Medicinal chemistry (Shariqah (United Arab Emirates)), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

2 authors.

Mohammad A KhanfarCollege of Pharmacy, Alfaisal University, Al Takhassusi Rd, Riyadh 11533, Saudi Arabia.

Mohammad SalehDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, P.O Box 13140, Amman 11942, Jordan.

Funding

College of Pharmacy and Office of Research and Innovation (ORI) at Alfaisal University 23520

6 · The paper itself

Abstract

introductionCarbonic anhydrase IX (CAIX) is known to be overexpressed in various tumors and plays a significant role in tumor development and progression.

methodsA series of 3-(benzylsulfonamido)benzamides derivatives was synthesized and tested for their CAIX inhibitory activities. The two most active compounds were subjected to cytotoxicity testing against a panel of 60 cancer cell lines.

resultsMany of the synthesized compounds successfully inhibited CAIX activities, exhibiting IC

conclusionThe synthesized analogues represent a novel scaffold for the treatment of different types of cancer by targeting CAIX.

Indexed as

Antigens, NeoplasmAntineoplastic AgentsBenzamidesCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXDrug DesignSulfonamidesCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansModels, MolecularMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAntigens, NeoplasmAntineoplastic AgentsBenzamidesCA9 protein, humanCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXSulfonamidescancerCarbonic anhydrasedockingNCI-60 human tumor.sulfonamidesynthesis

Identifiers

PMID40007186

DOI10.1038/sj.bjc.6605690

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.