Evidence map›Paper›PMID 40007183›Full record

ReviewMedicinal chemistry (Shariqah (United Arab Emirates))2025

Exploring Quinoline Derivatives: Their Antimalarial Efficacy and Structural Features.

Raghav Mishra, Jayze da Cunha Xavier, Nitin Kumar, Gaurav Krishna, Prashant Kumar Dhakad, Helcio Silva Dos Santos, Paulo Nogueira Bandeira, Tigressa Helena Soares Rodrigues, Diego Romao Gondim, Walber Henrique Ferreira Ribeiro and 5 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medicinal chemistry (Shariqah (United Arab Emirates)), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Raghav MishraDepartment of Pharmacy, Lloyd School of Pharmacy, Knowledge Park II, Greater Noida, Uttar Pradesh 201306, India.ORCID 0000-0001-5269-2860
Jayze da Cunha XavierDepartment of Biological Chemistry, Regional University of Cariri, Crato-CE, Brazil.ORCID 0000-0003-1942-3700
Nitin KumarDepartment of Pharmacy, Saraswathi College of Pharmacy, Anwarpur, Pilkhuwa, India.ORCID 0000-0001-9340-5514
Gaurav KrishnaDepartment of Pharmacy, GLA University, Mathura, 281406, Uttar Pradesh, India.ORCID 0000-0003-1398-9340
Prashant Kumar DhakadDepartment of Pharmacy, Suresh Gyan Vihar University, Gyan vihar Marg Jagatpura Jaipur, 302017, Rajasthan, India.
Helcio Silva Dos SantosDepartment of Biological Chemistry, Regional University of Cariri, Crato-CE, Brazil.ORCID 0000-0001-5527-164X
Paulo Nogueira BandeiraCenter for Exact Sciences and Technology - Chemistry Course, Vale do Acaraú University, Sobral, CE, Brazil.ORCID 0000-0001-5374-1839
Tigressa Helena Soares RodriguesCenter for Exact Sciences and Technology - Chemistry Course, Vale do Acaraú University, Sobral, CE, Brazil.ORCID 0000-0002-8044-3121
Diego Romao GondimCenter for Exact Sciences and Technology - Chemistry Course, Vale do Acaraú University, Sobral, CE, Brazil.
Walber Henrique Ferreira RibeiroCenter for Exact Sciences and Technology - Chemistry Course, Vale do Acaraú University, Sobral, CE, Brazil.
Draulio Sales da SilvaCenter for Exact Sciences and Technology - Chemistry Course, Vale do Acaraú University, Sobral, CE, Brazil.
Alexandre Magno Rodrigues TeixeiraDepartment of Biological Chemistry, Regional University of Cariri, Crato-CE, Brazil.ORCID 0000-0001-6786-2076
Wandresa Francelino PereiraRENORBIO Postgraduate Program, State University of Ceará, Fortaleza, CE, Brazil.
Emmanuel Silva MarinhoPostgraduate Program in Natural Sciences, State University of Ceara, Fortaleza, CE, Brazil.ORCID 0000-0002-4774-8775
SuchetaSchool of Medical & Allied Sciences, K.R. Mangalam University, Sohna Road, Gurugram, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesMalaria continues to be the primary cause of mortality worldwide, and timely recognition and prompt intervention are crucial in mitigating adverse consequences. This review article aims to examine the effectiveness and structural characteristics of quinoline-based compounds as antimalarial agents. It specifically focuses on their therapeutic effects as well as potential prospects for exploring structure-activity relationship (SAR). In addition, this study aims to identify lead compounds that can efficiently battle multidrug-resistant forms of

methodsA comprehensive review was conducted to evaluate the effectiveness of quinoline-based antimalarial medications in eradicating

resultsQuinoline-based antimalarials demonstrated significant effectiveness in eliminating

conclusionQuinoline-based compounds represent a promising avenue for combating malaria due to their demonstrated efficacy against

Indexed as

AntimalarialsPlasmodium falciparumQuinolinesHumansMolecular StructurePlasmodium vivaxStructure-Activity RelationshipAntimalarialsquinolineQuinolinesantimalarialdetoxification.malariaPlasmodiumQuinoline derivativesstructure-activity relationship

Identifiers

PMID40007183

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.