ArticleBriefings in bioinformatics2024
Revealing the antimicrobial potential of traditional Chinese medicine through text mining and molecular computation.
Article in Briefings in bioinformatics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Article
- Advances in UDP-Glycosyltransferases from Medicinal Plants: Discovery, Catalytic Mechanism, Engineering and Biosynthetic Application.Metabolites · 2026Review
- A Genome-based Machine Learning Model for Safety Assessment of Microorganisms.Probiotics and antimicrobial proteins · 2026Article
- Pharmacotherapy of the spleen and stomach in Li Shizhen's Bencao Gangmu (Compendium of materia medica, 1596): a text-statistical analysis of 994 entries and a bridge to modern pharmacology.Frontiers in pharmacology · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
Traditional Chinese Medicine (TCM), with its extensive knowledge base documented in ancient texts, offers a unique resource for contemporary drug discovery, particularly in combatting microbial infections. The success of antimalarial drugs like artemisinin and artesunate, derived from the TCM herb Artemisia annua L., exemplifies the potential of TCM-derived small molecules. This rich repository of natural products and intricate molecular structures could reveal novel compounds with unexplored mechanisms of action. Our study employs a multifaceted approach that combines text mining, detailed textual analysis, and modern antibacterial molecular prediction methodologies to unlock the potential of ancient TCM remedies. We use external knowledge maps, which include databases of known bioactive compounds and their targets, to identify promising TCM candidates. This approach leverages both historical texts and contemporary scientific data to explore the therapeutic potential of TCM. We discovered that herb patterns DiYu→ZeXie and Kushen→ShengJiang potentially combat both Grams-positive and Grams-negative bacteria. We utilized the AntiBac-Pred online tool to identify and analyze the chemical components of herbs, integrating data from ancient texts and TCMDB@Taiwan external knowledge graph. The DiYu→ZeXie groups showed antimicrobial potential against resistant Staphylococcus simulans, while the Kushen→ShengJiang groups exhibited dual antimicrobial effects against Bacillus subtilis. Exploring TCM's extensive repository offers numerous opportunities for discovering therapeutically active compounds. Our synergistic approach, which combines ancient wisdom with modern science, holds significant promise for enhancing our ability to combat infectious diseases. This method could pave the way for a new era of personalized medicine, addressing the urgent need for innovative treatments against multidrug-resistant bacteria and viruses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.