Evidence map›Paper›PMID 40007127›Full record

ArticleAnnals of clinical and translational neurology2025

High-Fat and Low-Carbohydrate Dietary Environments Are Linked to Reduced Idiopathic Epilepsy Incidence and Prevalence.

Duan Ni, Alistair Senior, David Raubenheimer, Stephen J Simpson, Ralph Nanan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Duan NiSydney Medical School Nepean, The University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-3902-2843
Alistair SeniorCharles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
David RaubenheimerCharles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
Stephen J SimpsonCharles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
Ralph NananSydney Medical School Nepean, The University of Sydney, Sydney, New South Wales, Australia.

Funding

Norman Ernest Bequest Fund
6 · The paper itself

Abstract

Dietary manipulations like ketogenic diets are established interventions for recalcitrant epilepsy. However, it remains unknown whether specific macronutrient exposure through dietary environments could possibly extend to primary preventive qualities, associated with changes in epilepsy disease burden (prevalence and incidence). Here, macronutrient supply, GDP, and idiopathic epilepsy disease burden data were collated from more than 150 countries from 1990 to 2018. Nutritional geometry generalized additive mixed models (GAMMs) modeling unraveled that dietary environments with high-fat and low-carbohydrate supplies were linked to lower epilepsy incidence and prevalence. Our analyses suggested a plausible primary preventive role of dietary manipulations for epilepsy.

Indexed as

Diet, Carbohydrate-RestrictedDiet, High-FatEpilepsyDiet, KetogenicHumansIncidencePrevalencedietary environmenthigh‐fat low‐carbohydrateidiopathic epilepsymacronutrient

Identifiers

PMID40007127
PMCPMC12093339

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.