ArticleViruses2025
Phylogenetic Analysis of Varicella-Zoster Virus in Cerebrospinal Fluid from Individuals with Acute Central Nervous System Infection: An Exploratory Study.
Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- An explainable machine learning model predicts pediatric varicella encephalitis.Frontiers in cellular and infection microbiology · 2026Article
- Metagenomic detection of central nervous system infections missedby conventional testing.JCI insight · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundThere is scarce information on Varicella-Zoster virus genetic variability in individuals with acute central nervous system infection in Brazil. The objective of this study was the molecular characterization of Varicella-Zoster virus isolates in cerebrospinal fluid from individuals with acute central nervous system infection.
methodsCerebrospinal fluid samples were collected from individuals evaluated in emergency and community healthcare services in São Paulo, Brazil. Varicella-Zoster virus identification was performed using commercial platforms Biofire-FilmArray Meningitis/Encephalitis (BioMérieux, Craponne, France) and XGEN-UMLTI-N9
resultsAmong the 600 cerebrospinal fluid samples, we identified Varicella-Zoster virus in 30 (5%) samples. None were positive for the vaccine-strain. Twelve samples were sequenced and phylogenetically classified into Clades 1 (41.7%), 2 (25%), 3 (8.3%), 5 (16.7%), or 6 (8%).
conclusionEnhanced characterization of circulating Varicella-Zoster virus Clades in Brazil identified previously unreported Clades 2 and 6 as well as three other Clades disseminated intercontinentally. These findings reinforce the importance of Varicella-Zoster virus molecular surveillance in cerebrospinal fluid.
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