Evidence map›Paper›PMID 40007033›Full record

ArticleViruses2025

Significant Association Between Increased Abundance of Selected Bacterial Lipopolysaccharides and Norovirus Diarrhea Among South African Infants.

Lerato P Kgosana, Mapaseka L Seheri, Cliff A Magwira

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lerato P KgosanaDiarrheal Pathogens Research Unit (DPRU), Department of Medical Virology, Sefako Makgatho Health Sciences University, Pretoria 0208, South Africa.ORCID 0000-0002-1903-5276
Mapaseka L SeheriDiarrheal Pathogens Research Unit (DPRU), Department of Medical Virology, Sefako Makgatho Health Sciences University, Pretoria 0208, South Africa.
Cliff A MagwiraDiarrheal Pathogens Research Unit (DPRU), Department of Medical Virology, Sefako Makgatho Health Sciences University, Pretoria 0208, South Africa.ORCID 0000-0002-4081-6886

Funding

National Research Foundation (SA) N/ASouth African Medical Research Council N/A
6 · The paper itself

Abstract

Bacterial lipopolysaccharides (LPS) have been shown to promote enteric viral infections. This study assessed whether possessing elevated levels of LPS was associated with norovirus infection. Fecal samples from diarrheic norovirus-positive (DNP) (n = 26), non-diarrheal norovirus-negative (NDNN) (n = 26), asymptomatic norovirus-positive (ANP) (n = 15), and diarrheic norovirus-negative (DNN) (n =15) infants were assayed for selected bacterial LPS by quantitative PCR. The mean levels of selected LPS gene targets were significantly high in DNP infants (6.17 ± 2.14 CFU/g) versus NDNN infants (4.13 ± 2.25 CFU/g),

Indexed as

BacteriaCaliciviridae InfectionsDiarrheaLipopolysaccharidesNorovirusFecesFemaleGastroenteritisHumansInfantMaleSouth AfricaToll-Like Receptor 4LipopolysaccharidesTLR4 protein, humanToll-Like Receptor 4abundancebacterial lipopolysaccharidegene expressionnorovirus diarrheaTLR4

Identifiers

PMID40007033
PMCPMC11860319

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.