Evidence map›Paper›PMID 40007022›Full record

ArticleViruses2025

The Angiogenic Markers PlGF and sFlt-1 in Cytomegalovirus Infection During Pregnancy: Insights from a Clinical Case.

Valentina Giardini, Ramona Chiozzi, Federica Fernicola, Marco Casati, Anna Locatelli, Sara Ornaghi

Abstract readCase Reports
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Valentina GiardiniUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.ORCID 0000-0002-6010-9994
Ramona ChiozziSpecialization School in Obstetrics and Gynecology, University of Milano-Bicocca, 20900 Monza, Italy.
Federica FernicolaUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.ORCID 0009-0004-1642-8770
Marco CasatiLaboratory Medicine, Foundation IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.ORCID 0000-0002-4968-1455
Anna LocatelliUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.ORCID 0000-0002-3919-4776
Sara OrnaghiUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.ORCID 0000-0001-6898-7217

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytomegalovirus (CMV) infection during pregnancy is the leading cause of congenital infection subsequent to viral transplacental transmission. CMV placental infection can contribute to the development of adverse outcomes likely through placental dysfunction. This case report shows the potential utility of angiogenic markers, such as placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1), in assessing CMV-related placental involvement and monitoring the effect of antiviral therapy on placental function, and highlights the possibility of integrating these markers into the clinical management of CMV infection.

Indexed as

Cytomegalovirus InfectionsPlacenta Growth FactorPregnancy Complications, InfectiousVascular Endothelial Growth Factor Receptor-1AdultAntiviral AgentsBiomarkersCytomegalovirusFemaleHumansInfectious Disease Transmission, VerticalPlacentaPregnancyAntiviral AgentsBiomarkersFLT1 protein, humanPGF protein, humanPlacenta Growth FactorVascular Endothelial Growth Factor Receptor-1angiogenic markerscytomegalovirusinfectionplacental dysfunctionPlGFsFlt-1sFlt-1/PlGF

Identifiers

PMID40007022
PMCPMC11860600

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.