Evidence map›Paper›PMID 40007000›Full record

ArticleViruses2025

First Reported Case of Integrase Strand Transfer Inhibitor Resistance in Suriname: Unusual Drug Resistance Mutations Following Exposure to Dolutegravir.

Rachel C Sno, Gracia Culbard, Malti R Adhin

Abstract readCase Reports
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rachel C Sno"Prof. Dr. Paul C. Flu" Institute for Biomedical Sciences, Kernkampweg 5, Paramaribo, Suriname.
Gracia CulbardAcademic Hospital Suriname, Flustraat 29, Paramaribo, Suriname.
Malti R AdhinFaculty of Medical Sciences, Department of Biochemistry, Anton de Kom Universiteit van Suriname, Kernkampweg 5, Paramaribo, Suriname.ORCID 0000-0002-2001-9994

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Contemporary ART as Dolutegravir (DTG) has significantly advanced antiretroviral therapy, but relatively few data are available on its impact on the emergence of HIV-1 drug resistance mutations (DRMs). Monitoring the emergence of INSTI-associated DRMs following the introduction of DTG in Suriname will provide general insight and guide national HIV treatment strategies. All people living with HIV (PLHIV) in Suriname, for whom an INSTI drug resistance test was requested between September 2019 and February 2024 (

Indexed as

Drug Resistance, ViralHeterocyclic Compounds, 3-RingHIV-1HIV InfectionsHIV IntegraseHIV Integrase InhibitorsOxazinesPiperazinesPyridonesDolutegravirHumansMutationSurinameDolutegravirHeterocyclic Compounds, 3-RingHIV IntegraseHIV Integrase InhibitorsOxazinesp31 integrase protein, Human immunodeficiency virus 1PiperazinesPyridonesdolutegravirdrug resistance mutationsHIV-1 integraseINSTI resistanceSuriname

Identifiers

PMID40007000
PMCPMC11860197

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.