Evidence map›Paper›PMID 40006993›Full record

Observational studyViruses2025

Neurological, Radiological, Visual, and Auditory Findings in Children with Intrauterine Exposure to the Zika Virus.

Marlos Melo Martins, Andréa Bittencourt Guastavino, Maria Clara de Magalhães-Barbosa, Maria Helena de Magalhães-Barbosa, Cristiane Fregonesi Dutra Garcia, Bárbara Karine Gonet Amaral, Annamaria Ciminelli Barbosa, Halina Cidrini Ferreira, Jaqueline Rodrigues Robaina, Mariana Barros Genuino de Oliveira and 5 more

Abstract readObservational Study
In one paragraph

Observational study in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Marlos Melo MartinsDivision of Pediatric Neurology, Martagão Gesteira Institute of Childcare and Pediatrics (IPPMG), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-912, RJ, Brazil.
Andréa Bittencourt GuastavinoNeonatal Unit, Maternity School Hospital, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-001, RJ, Brazil.
Maria Clara de Magalhães-BarbosaDepartment of Pediatrics, D'Or Institute for Research and Education (IDOR), Rio de Janeiro 22281-100, RJ, Brazil.ORCID 0000-0003-0959-0775
Maria Helena de Magalhães-BarbosaPhonoaudiology Unit, Maternity School Hospital, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-001, RJ, Brazil.
Cristiane Fregonesi Dutra GarciaPhonoaudiology Unit, Maternity School Hospital, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-001, RJ, Brazil.ORCID 0000-0002-8201-3918
Bárbara Karine Gonet AmaralDepartment of Ophthalmology, Maternity School Hospital, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-001, RJ, Brazil.
Annamaria Ciminelli BarbosaDepartment of Ophthalmology, Gaffree and Guinle University Hospital, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro 20270-004, RJ, Brazil.
Halina Cidrini FerreiraDepartment of Physiotherapy, Maternity School Hospital, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-001, RJ, Brazil.
Jaqueline Rodrigues RobainaDepartment of Pediatrics, D'Or Institute for Research and Education (IDOR), Rio de Janeiro 22281-100, RJ, Brazil.ORCID 0000-0003-1483-9029
Mariana Barros Genuino de OliveiraDepartment of Pediatrics, D'Or Institute for Research and Education (IDOR), Rio de Janeiro 22281-100, RJ, Brazil.ORCID 0000-0002-2734-8205
Fernanda Freire Tovar-MollDepartment of Radiology, D'Or Institute for Research and Education (IDOR), Rio de Janeiro 22281-100, RJ, Brazil.
Roberto de Andrade MedronhoDepartment of Epidemiology and Public Health, School of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21044-020, RJ, Brazil.ORCID 0000-0003-4073-3930
Antonio José Ledo Alves da CunhaDepartment of Pediatrics, D'Or Institute for Research and Education (IDOR), Rio de Janeiro 22281-100, RJ, Brazil.
Joffre AmimPostgraduate Program, Maternity School Hospital, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-001, RJ, Brazil.
Arnaldo Prata-BarbosaPostgraduate Program, Maternity School Hospital, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-001, RJ, Brazil.ORCID 0000-0002-4726-9782

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to describe neurological, visual, and auditory findings in children whose mothers had confirmed Zika virus (ZIKV) infection during pregnancy, with most of these children not presenting congenital microcephaly; Methods: an observational, longitudinal, and prospective study was conducted in Rio de Janeiro, Brazil, from March 2015 to January 2017, involving children with in utero exposure to Zika virus, following from birth up to 30 months of age. Results: Of the 2882 pregnant women admitted, 116 had a suspected ZIKV infection, of whom 33 had laboratory confirmation. Only one child presented with congenital microcephaly. Despite this, neurodevelopment delay was observed in 36.4% of children evaluated, radiological abnormalities in 29.1%, auditory abnormalities in 8.3%, and ophthalmological abnormalities in 10%. Conclusions: Newborns of mothers with confirmed ZIKV infection during pregnancy may present with varying degrees of visual, auditory, and neurological impairment, despite the presence of congenital microcephaly.

Indexed as

Pregnancy Complications, InfectiousZika VirusZika Virus InfectionAdultBrazilChild, PreschoolFemaleHumansInfantInfant, NewbornLongitudinal StudiesMaleMicrocephalyPregnancyProspective Studiesauditory disordersinfantile developmentmicrocephalyradiological abnormalitiesvisual disordersZika virus

Identifiers

PMID40006993
PMCPMC11861632

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.