Evidence map›Paper›PMID 40006968›Full record

ArticleViruses2025

Molecular Characterization of the Infectious Laryngotracheitis Virus (ILTV) Involved in Poultry Outbreaks Reveals the Virus Origin and Estimated Spreading Route.

Jorge Luis Chacón, Ruy D Chacón, Henrique Lage Hagemann, Claudete S Astolfi-Ferreira, Cesar Nunes, Luiz Sesti, Branko Alva, Antonio J Piantino Ferreira

Abstract read
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jorge Luis ChacónCEVA Animal Health, Rua Manoel Joaquim Filho, 303, São Paulo 13148-115, Brazil.
Ruy D ChacónDepartment of Pathology, School of Veterinary Medicine, University of São Paulo, Av. Prof. Orlando Marques de Paiva, 87, São Paulo 05508-900, Brazil.ORCID 0000-0002-1044-7450
Henrique Lage HagemannDepartment of Pathology, School of Veterinary Medicine, University of São Paulo, Av. Prof. Orlando Marques de Paiva, 87, São Paulo 05508-900, Brazil.
Claudete S Astolfi-FerreiraDepartment of Pathology, School of Veterinary Medicine, University of São Paulo, Av. Prof. Orlando Marques de Paiva, 87, São Paulo 05508-900, Brazil.
Cesar NunesCEVA Animal Health, Rua Manoel Joaquim Filho, 303, São Paulo 13148-115, Brazil.
Luiz SestiCEVA Animal Health, Rua Manoel Joaquim Filho, 303, São Paulo 13148-115, Brazil.
Branko AlvaCEVA Animal Health, Rua Manoel Joaquim Filho, 303, São Paulo 13148-115, Brazil.
Antonio J Piantino FerreiraDepartment of Pathology, School of Veterinary Medicine, University of São Paulo, Av. Prof. Orlando Marques de Paiva, 87, São Paulo 05508-900, Brazil.ORCID 0000-0002-0086-5181

Funding

Ceva Saúde Animal Ltda. APCNational Council for Scientific and Technological Development 301084/2019-0
6 · The paper itself

Abstract

Infectious laryngotracheitis outbreaks have been observed in a short period of time in broiler, layer, and broiler breeder flocks, resulting in clinical signs and high mortality. The affected farms are located in the same geographical area, which is a high-density poultry region of Brazil. To estimate the potential origin of the virus or viruses that caused the outbreaks, the ILTVs detected at six companies were molecularly characterized by sequencing two fragments of the ICP4 gene and then compared with previous field and vaccine viruses detected in the country. The sequencing results revealed that all farms investigated were infected with a nonvaccine-origin virus. Phylogenetic analysis revealed that all farms were infected by the same virus classified as genotype VI. In addition, the ILTV detected in the present study was compared with that of viruses previously detected in egg-layer poultry regions in the country. The viruses detected in the recent outbreaks were indistinguishable, with one of them (VI-4) suggesting a possible route of transmission. This study describes for the first time severe ILT outbreaks in meat-type poultry in Brazil that spread quickly, and the phylogenetic analysis suggests the potential origin of the virus and route of transmission.

Indexed as

Disease OutbreaksHerpesviridae InfectionsHerpesvirus 1, GallidPoultry DiseasesAnimalsBrazilChickensGenotypePhylogenyPoultrychickenGallid alphaherpesvirus 1infected cell protein 4infectious laryngotracheitis virusmolecular characterization

Identifiers

PMID40006968
PMCPMC11860664

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.