Evidence map›Paper›PMID 40006735›Full record

ArticleVaccines2025

Safety and Efficacy of Influenza Vaccination in Kidney Graft Recipients in Late Period After Kidney Transplantation.

Anna Zawiasa-Bryszewska, Maja Nowicka, Monika Górska, Piotr Edyko, Krzysztof Edyko, Damian Tworek, Adam Antczak, Jacek Burzyński, Ilona Kurnatowska

Abstract read
In one paragraph

Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anna Zawiasa-BryszewskaDepartment of Internal Medicine and Transplant Nephrology, Medical University of Lodz, 90-419 Lodz, Poland.
Maja NowickaDepartment of Internal Medicine and Transplant Nephrology, Medical University of Lodz, 90-419 Lodz, Poland.ORCID 0000-0001-6587-2502
Monika GórskaDepartment of Internal Medicine and Transplant Nephrology, Medical University of Lodz, 90-419 Lodz, Poland.ORCID 0000-0002-5626-8511
Piotr EdykoDepartment of Internal Medicine and Transplant Nephrology, Medical University of Lodz, 90-419 Lodz, Poland.
Krzysztof EdykoStudent Scientific Society Affiliated with the Department of Internal Medicine and Transplant Nephrology, Chair of Pulmonology, Rheumatology and Clinical Immunology, Medical University of Lodz, 90-419 Lodz, Poland.
Damian TworekDepartment of General and Oncological Pulmonology, Medical University of Lodz, 90-419 Lodz, Poland.ORCID 0000-0001-9862-6703
Adam AntczakDepartment of General and Oncological Pulmonology, Medical University of Lodz, 90-419 Lodz, Poland.
Jacek BurzyńskiDepartment of Statistics and Translational Medicine, Medical University of Lodz, 90-419 Lodz, Poland.
Ilona KurnatowskaDepartment of Internal Medicine and Transplant Nephrology, Medical University of Lodz, 90-419 Lodz, Poland.ORCID 0000-0003-3448-0682

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesInfluenza is a viral infection affecting up to 20% of the general population annually. Solid organ transplant recipients have a higher morbidity and mortality risk, as well as a greater likelihood of severe disease complications. Vaccination against the influenza virus is a safe and recommended prophylaxis; however, immunosuppression and high comorbidity burdens impair the immune response. We assessed the efficacy, safety, and humoral response to influenza vaccine in a population of kidney transplant recipients (KTx).

methodsAdult KTx recipients at least 6 months post-KTx were divided into vaccinated (vKTx) and non-vaccinated (nvKTx) groups based on consent for vaccination. The vKTx group received one dose of quadrivalent split virion inactivated vaccine (Vaxigrip Tetra Sanofi Pasteur). Subjective symptoms and side effects were recorded in paper journals. Antibody levels were assessed with ELISA prior to and 3 months following vaccination. Serum creatinine and proteinuria were assessed prior to vaccination as well as 3 and 6 months after.

resultsOf 450 recruited KTx recipients, 91 in the vKTx group and 36 in the nvKTx group of comparable age, KTx vintage, and graft function were included in the study. Graft function and proteinuria remained stable in both groups. The vKTx group experienced no severe adverse events. The most common complaints were general malaise (20.5%) and injection site pain (10.3%). Overall infection rates were comparable, yet the vKTx group experienced significantly fewer serious infections (11.4% vs. 32.3%,

conclusionsInfluenza vaccination prevents severe infections in KTx recipients, with good serological response and no impact on graft function or severe adverse events.

Indexed as

antibody responseinfluenza virustransplant recipients

Identifiers

PMID40006735
PMCPMC11861709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.