Evidence map›Paper›PMID 40006734›Full record

ArticleVaccines2025

Generation of Vaccine Candidate Strains That Antigenically Match Classical Swine Fever Virus Field Strains.

Maya Kobayashi, Loc Tan Huynh, Saho Ogino, Lim Yik Hew, Miki Koyasu, Hikaru Kamata, Takahiro Hiono, Norikazu Isoda, Yoshihiro Sakoda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maya KobayashiLaboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.
Loc Tan HuynhLaboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.ORCID 0000-0001-9922-4802
Saho OginoLaboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.
Lim Yik HewLaboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.
Miki KoyasuGifu Central Livestock Hygiene Service Center, Gifu 501-1112, Japan.
Hikaru KamataGifu Hida Livestock Hygiene Service Center, Gifu 506-8688, Japan.
Takahiro HionoLaboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.
Norikazu IsodaLaboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.ORCID 0000-0003-3480-988X
Yoshihiro SakodaLaboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.ORCID 0000-0001-7021-1688

Funding

the Japan Agency for Medical Research and Development JP223fa627005the Japan Agency for Medical Research and Development JP243fa627005the Ministry of Agriculture, Forestry and Fisheries of Japan JPJ008617.20319390the Ministry of Education, Culture, Sports, Science and Technology JP22H02504the WISE Grant-in-Aid for Graduate Students, Program for One Health Frontier of Graduate School of Excellence, Hokkaido University PH36210001
6 · The paper itself

Abstract

backgroundClassical swine fever virus (CSFV) is genetically categorized into three genotypes. A live-attenuated vaccine strain GPE

methodsThe serum samples of 20 pigs vaccinated with GPE

resultsThe SNT titers of serum sample against Mie/2019 were 6.1-fold lower than that against vGPE

conclusionsThis study demonstrated that swapping the E2 encoding region with the prevalent field CSFVs is a promising strategy to achieve antigenic matching between the vaccine and field strains.

Indexed as

antigenicitychimeric vaccineclassical swine fever virusE2 envelope glycoproteinpestivirus

Identifiers

PMID40006734
PMCPMC11860266

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.