Evidence map›Paper›PMID 40006726›Full record

ReviewVaccines2025

Leveraging Electron Beam (eBeam) Technology for Advancing the Development of Inactivated Vaccines.

Ruvindu Perera, Suresh D Pillai, Adnan Alrubaye, Palmy Jesudhasan

Abstract readReview
In one paragraph

Review in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Pathogenic mechanisms and vaccine development forFrontiers in microbiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ruvindu PereraCell and Molecular Biology Program, University of Arkansas, Fayetteville, AR 72701, USA.
Suresh D PillaiNational Center for Electron Beam Research, Texas A&M University, College Station, TX 77840, USA.
Adnan AlrubayeCell and Molecular Biology Program, University of Arkansas, Fayetteville, AR 72701, USA.ORCID 0000-0002-5122-9150
Palmy JesudhasanPoultry Production and Product Safety Research Unit, USDA-ARS, Fayetteville, AR 72701, USA.ORCID 0000-0001-9128-4544

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review provides an overview of electron beam (eBeam) technology and its applications across a wide variety of disciplines. More importantly, it discusses this technology's advantages and its benefits in developing inactivated vaccines. eBeam technology is currently being used all around the world for a variety of industrial applications, extending from food pasteurization to the cross-linking of polymers in the wire and cable industries. It is a successful emerging alternative for developing vaccines against bacterial, protozoan, and viral pathogens. This review includes a descriptive account of the mechanism of action of eBeam and how this technology achieves the complete inactivation of pathogens while retaining the integrity of their surface epitopes. This unique advantage is crucial for the production of efficacious vaccines. This review provides a detailed account of the usage of eBeam technology for developing vaccines to protect a multitude of hosts against a wide range of pathogens. eBeam-inactivated vaccines are advantageous over live vaccines, RNA/subunit vaccines, and chemically inactivated vaccines mainly due to the complete inactivation of pathogens, and the presence of intact, highly antigenic epitopes. To conclude, this article descriptively highlights eBeam technology's advantages over other means of vaccine development.

Indexed as

bacteriaeBeamelectron beaminactivated vaccinesradiationvirus

Identifiers

PMID40006726
PMCPMC11861765

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.