ArticleVaccines2025
Vertical and Horizontal Transmission of Neosporosis in Three Consecutive Pregnancies of Naturally Infected Pregnant Cows and the Effect of Vaccination on Abortion Rates.
Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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6 authors.
Funding
Abstract
BACKGROUND/
objectivesNeosporosis is a major cause of abortions in cattle worldwide. Primary results showed that the administration of a live attenuated vaccine during the mid-pregnancy stage of naturally infected cows may assist in preventing abortions. In this study, the effect of vaccination was evaluated in five dairy herds, with a follow-up of three consecutive pregnancies and re-vaccination during the subsequent pregnancies of some of the cows.
methodsA total of 1059 heifers were serologically tested during their first pregnancy, and 260 and 21 of them were re-tested during their second and third pregnancies. Vaccination was administered to 193 of 420 cows with antibody titers of 1:800 or higher, and 23 of them were re-vaccinated. Data were collected regarding the outcome of each pregnancy, the number of inseminations required and removal from the herd. Vertical transmission was evaluated in 136 pre-colostral calves born from 29 vaccinated and 107 unvaccinated dams.
resultsThe total seroprevalence using a cutoff titer of 1:800 was 33.1, 36.5 and 85.7% during the three consecutive pregnancies. The antibody titers of individual cows fluctuated over time. Abortion rates and the rate of removal from the herd were significantly higher in seropositive cows. The rate of vertical transmission increased in correlation with the dam's antibody titer. Immunization resulted in lower abortion rates at two of the farms. Vaccine efficacy ranged from a negative effect to 54% at different farms, with an overall efficacy of 10.4%. The effect of vaccination on abortions, reproductive performance, antibody titers, vertical transmission and removal from the herd was not significant.
conclusionsThese results demonstrate varying vaccine efficacies among farms and suggest that neosporosis is a multifactorial disease that cannot be solely controlled by vaccination.
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