Evidence map›Paper›PMID 40006664›Full record

ArticleVaccines2025

A Phase II Study of Denileukin Diftitox in Patients with Advanced Treatment Refractory Breast Cancer.

William R Gwin, Lupe G Salazar, James Y Dai, Doreen Higgins, Andrew L Coveler, Jennifer S Childs, Rosie Blancas, Yushe Dang, Jessica Reichow, Meredith Slota and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

William R GwinCancer Vaccine Institute, University of Washington, 850 Republican Street, Box 358050, Seattle, WA 98195, USA.ORCID 0000-0001-6314-0965
Lupe G SalazarCancer Vaccine Institute, University of Washington, 850 Republican Street, Box 358050, Seattle, WA 98195, USA.
James Y DaiFred Hutchinson Cancer Center, 1100 Fairview Ave. N., Seattle, WA 98109, USA.
Doreen HigginsCancer Vaccine Institute, University of Washington, 850 Republican Street, Box 358050, Seattle, WA 98195, USA.
Andrew L CovelerCancer Vaccine Institute, University of Washington, 850 Republican Street, Box 358050, Seattle, WA 98195, USA.ORCID 0000-0003-1710-5637
Jennifer S ChildsCancer Vaccine Institute, University of Washington, 850 Republican Street, Box 358050, Seattle, WA 98195, USA.
Rosie BlancasBreastlink Medical Group, 230 S Main St, #100, Orange County, CA 92868, USA.
Yushe DangCancer Vaccine Institute, University of Washington, 850 Republican Street, Box 358050, Seattle, WA 98195, USA.ORCID 0000-0002-7661-0855
Jessica ReichowCancer Vaccine Institute, University of Washington, 850 Republican Street, Box 358050, Seattle, WA 98195, USA.
Meredith SlotaCancer Vaccine Institute, University of Washington, 850 Republican Street, Box 358050, Seattle, WA 98195, USA.ORCID 0000-0001-8492-6705
Hailing LuSeattle Genetics (Pfizer), 21823 30th DR SE, Bothell, WA 98021, USA.
Mary L DisisCancer Vaccine Institute, University of Washington, 850 Republican Street, Box 358050, Seattle, WA 98195, USA.ORCID 0000-0001-7653-4648

Funding

Phase-I-II Study of DAB389 (ONTAK) in Patients with Adv. Refractory Breast CancerR21CA114958 · NCI · UNIVERSITY OF WASHINGTON · PI SALAZAR, LUPE G · 2006 to 2007
$513k
NCI NIH HHS R21 CA114958
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

breast cancerdenileukin diftitoximmunityregulatory T-cellstumor microenvironment

Identifiers

PMID40006664
PMCPMC11860294

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.