Evidence map›Paper›PMID 40006622›Full record

ArticlePharmaceutics2025

Phytoactive-Loaded Lipid Nanocarriers for Simvastatin Delivery: A Drug Repositioning Strategy Against Lung Cancer.

Rocío Gambaro, Cecilia Y Chain, Sebastian Scioli-Montoto, Ailin Moreno, Cristián Huck-Iriart, María Esperanza Ruiz, José S Cisneros, Diego G Lamas, Julia Tau, Stephan Gehring and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rocío GambaroChildren's Hospital, University Medical Center of the Johannes, Gutenberg University, Langenbeckstr. 1, 55131 Mainz, Germany.
Cecilia Y ChainInstituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET)-Universidad Nacional de La Plata (UNLP), La Plata 1900, Buenos Aires, Argentina.ORCID 0000-0002-8234-0556
Sebastian Scioli-MontotoLaboratorio de Investigación y Desarrollo de Bioactivos (LIDeB), Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata 1900, Buenos Aires, Argentina.ORCID 0000-0003-3314-3406
Ailin MorenoInstituto de Investigaciones Bioquímicas de La Plata (INIBIOLP), Investigaciones Científicas y Tecnológicas (CONICET)-Universidad Nacional de La Plata (UNLP), CCT-La Plata, Facultad de Ciencias Médicas UNLP, La Plata 1900, Buenos Aires, Argentina.
Cristián Huck-IriartInstituto de Tecnologías Emergentes y Ciencias Aplicadas (ITECA), Universidad Nacional de San Martín (UNSAM)--Investigaciones Científicas y Tecnológicas (CONICET), Escuela de Ciencia y Tecnología (ECyT), Laboratorio de Cristalografía Aplicada (LCA), Campus Miguelete, San Martín 1650, Buenos Aires, Argentina.ORCID 0000-0001-5734-2499
María Esperanza RuizLaboratorio de Investigación y Desarrollo de Bioactivos (LIDeB), Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata 1900, Buenos Aires, Argentina.ORCID 0000-0001-8617-667X
José S CisnerosInstituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET)-Universidad Nacional de La Plata (UNLP), La Plata 1900, Buenos Aires, Argentina.ORCID 0000-0001-7563-978X
Diego G LamasInstituto de Tecnologías Emergentes y Ciencias Aplicadas (ITECA), Universidad Nacional de San Martín (UNSAM)--Investigaciones Científicas y Tecnológicas (CONICET), Escuela de Ciencia y Tecnología (ECyT), Laboratorio de Cristalografía Aplicada (LCA), Campus Miguelete, San Martín 1650, Buenos Aires, Argentina.ORCID 0000-0002-9099-586X
Julia TauInstituto de Investigaciones Bioquímicas de La Plata (INIBIOLP), Investigaciones Científicas y Tecnológicas (CONICET)-Universidad Nacional de La Plata (UNLP), CCT-La Plata, Facultad de Ciencias Médicas UNLP, La Plata 1900, Buenos Aires, Argentina.ORCID 0000-0001-8684-7023
Stephan GehringChildren's Hospital, University Medical Center of the Johannes, Gutenberg University, Langenbeckstr. 1, 55131 Mainz, Germany.ORCID 0000-0002-9755-9155
Germán A IslanChildren's Hospital, University Medical Center of the Johannes, Gutenberg University, Langenbeckstr. 1, 55131 Mainz, Germany.ORCID 0000-0002-3275-1349
Boris Rodenak-KladniewInstituto de Investigaciones Bioquímicas de La Plata (INIBIOLP), Investigaciones Científicas y Tecnológicas (CONICET)-Universidad Nacional de La Plata (UNLP), CCT-La Plata, Facultad de Ciencias Médicas UNLP, La Plata 1900, Buenos Aires, Argentina.ORCID 0000-0001-6963-0690

Funding

Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación PICT2019-00199Consejo Nacional de Investigaciones Científicas y Técnicas PIBAA 0072, PIBAA 1078, PIP 0034, PIP 2051, PUE 0010Deutsche Forschungsgemeinschaft grant number B5 (M. S. and S. G.) SFB1066.Universidad Nacional de La Plata PPIDX077
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

anticancer mechanismsbioactive lipid nanoparticlesdrug repositioninglung cancerplant-derived monoterpenessimvastatinsynergism

Identifiers

PMID40006622
PMCPMC11858925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.