Evidence map›Paper›PMID 40006606›Full record

ArticlePharmaceutics2025

Uptake and Inhibition of P-Glycoprotein-Mediated Efflux Evaluation of Encapsulated Methotrexate Chitosan and Hypromellose Phthalate Nanoparticles for Potential Glioblastoma Treatment.

Valéria de Moura Leite Naves, Rafaela Franco Dias Bruzadelli, Marisa Ionta, Maria Palmira Daflon Gremião, Liliane Neves Pedreiro, Gislaine Ribeiro Pereira, Flávia Chiva Carvalho

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Valéria de Moura Leite NavesDepartment of Food and Drugs, Federal University of Alfenas, UNIFAL-MG, Alfenas 37130-001, MG, Brazil.
Rafaela Franco Dias BruzadelliDepartment of Food and Drugs, Federal University of Alfenas, UNIFAL-MG, Alfenas 37130-001, MG, Brazil.
Marisa IontaInstitute of Biomedicals Sicences, Federal University of Alfenas, UNIFAL-MG, Alfenas 37130-001, MG, Brazil.
Maria Palmira Daflon GremiãoDepartment of Drugs and Medicines, School of Pharmaceutical Sciences, State University of São Paulo State, UNESP, Araraquara 14800-903, SP, Brazil.ORCID 0000-0001-6950-7852
Liliane Neves PedreiroDepartment of Drugs and Medicines, School of Pharmaceutical Sciences, State University of São Paulo State, UNESP, Araraquara 14800-903, SP, Brazil.
Gislaine Ribeiro PereiraDepartment of Food and Drugs, Federal University of Alfenas, UNIFAL-MG, Alfenas 37130-001, MG, Brazil.
Flávia Chiva CarvalhoDepartment of Food and Drugs, Federal University of Alfenas, UNIFAL-MG, Alfenas 37130-001, MG, Brazil.

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 1241/2014Fundação de Amparo à Pesquisa do Estado de Minas Gerais CDS APQ 00465/14National Council for Scientific and Technological Development 454679/2014-9
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

chitosancross-linked polyelectrolyte complexeshypromellose phthalatemethotrexatep-glycoprotein-mediated efflux

Identifiers

PMID40006606
PMCPMC11859166

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.